Chiral Template Approach to 1,2-Disubstituted Carbacephem Antibiotics

Highly Chemoselective Reactions of Bicyclic Lactam Intermediates Bearing Multi-Carbonyl Functions with Nucleophiles

Seiki Saito, Teruhiko Ishikawa, Toshio Moriwake

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Diazabicyclio[4.2.0]-system consisted of N-(p-methoxyphenyl)-β-lactam and N′-Boc-δ-lactam subunits undergoes highly chemoselective reaction with various carbon nucleophiles at the carbonyl group of the δ-lactam-ring to give substituted β-lactam derivatives as precursors required for 1,2-disubstituted carbacephem antibiotics.

Original languageEnglish
Pages (from-to)139-140
Number of pages2
JournalSynlett
Volume1993
Issue number2
DOIs
Publication statusPublished - Feb 1 1993

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Bearings (structural)
Lactams
Nucleophiles
Anti-Bacterial Agents
Carbon
Derivatives
carbacephems

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

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abstract = "Diazabicyclio[4.2.0]-system consisted of N-(p-methoxyphenyl)-β-lactam and N′-Boc-δ-lactam subunits undergoes highly chemoselective reaction with various carbon nucleophiles at the carbonyl group of the δ-lactam-ring to give substituted β-lactam derivatives as precursors required for 1,2-disubstituted carbacephem antibiotics.",
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