Chiral Template Approach to 1,2-Disubstituted Carbacephem Antibiotics: Highly Chemoselective Reactions of Bicyclic Lactam Intermediates Bearing Multi-Carbonyl Functions with Nucleophiles

Seiki Saito; Teruhiko Ishikawa; Toshio Moriwake

doi:10.1055/s-1993-22379

Chiral Template Approach to 1,2-Disubstituted Carbacephem Antibiotics: Highly Chemoselective Reactions of Bicyclic Lactam Intermediates Bearing Multi-Carbonyl Functions with Nucleophiles

Seiki Saito, Teruhiko Ishikawa, Toshio Moriwake

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Diazabicyclio[4.2.0]-system consisted of N-(p-methoxyphenyl)-β-lactam and N′-Boc-δ-lactam subunits undergoes highly chemoselective reaction with various carbon nucleophiles at the carbonyl group of the δ-lactam-ring to give substituted β-lactam derivatives as precursors required for 1,2-disubstituted carbacephem antibiotics.

Original language	English
Pages (from-to)	139-140
Number of pages	2
Journal	Synlett
Volume	1993
Issue number	2
DOIs	https://doi.org/10.1055/s-1993-22379
Publication status	Published - Feb 1993

ASJC Scopus subject areas

Organic Chemistry

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abstract = "Diazabicyclio[4.2.0]-system consisted of N-(p-methoxyphenyl)-β-lactam and N′-Boc-δ-lactam subunits undergoes highly chemoselective reaction with various carbon nucleophiles at the carbonyl group of the δ-lactam-ring to give substituted β-lactam derivatives as precursors required for 1,2-disubstituted carbacephem antibiotics.",

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AU - Ishikawa, Teruhiko

AU - Moriwake, Toshio

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AB - Diazabicyclio[4.2.0]-system consisted of N-(p-methoxyphenyl)-β-lactam and N′-Boc-δ-lactam subunits undergoes highly chemoselective reaction with various carbon nucleophiles at the carbonyl group of the δ-lactam-ring to give substituted β-lactam derivatives as precursors required for 1,2-disubstituted carbacephem antibiotics.

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Chiral Template Approach to 1,2-Disubstituted Carbacephem Antibiotics: Highly Chemoselective Reactions of Bicyclic Lactam Intermediates Bearing Multi-Carbonyl Functions with Nucleophiles

Abstract

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