Chiral scandium-catalyzed enantioselective hydroxymethylation of ketones in water

Shu Kobayashi, Masaya Kokubo, Katsuaki Kawasumi, Takashi Nagano

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Scandium-catalyzed enantioselective hydroxymethylation of ketones has been developed using aqueous formaldehyde (formalin) in water. The addition of a catalytic amount of pyridine enables the use of ketones directly in asymmetric hydroxymethylation reactions. (Chemical equation presented).

Original languageEnglish
Pages (from-to)490-492
Number of pages3
JournalChemistry - An Asian Journal
Volume5
Issue number3
DOIs
Publication statusPublished - Mar 1 2010

Keywords

  • Asymmetric catalysis
  • Green chemistry
  • Hydroxymethylation
  • Scandium
  • Water

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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