Chiral Lewis acid-Hydroxylamine Hybrid Reagent for enantioselective Michael addition reaction directed towards β-amino acids synthesis

Teruhiko Ishikawa, Keita Nagai, Takayuki Kudoh, Seiki Saito

Research output: Contribution to journalArticle

25 Citations (Scopus)


We have succeeded in introducing a chiral auxiliary tethered by an appropriate metal into the hydroxy group of N-benzylhydroxylamine. The thus-obtained recyclable chiral reagent can act as an amine nucleophile to give chiral isoxazolidinones (up to 71% ee) as a β-amino acid synthon on the reaction with α,β-unsaturated carbonyl compounds.

Original languageEnglish
Pages (from-to)1291-1293
Number of pages3
Issue number11
Publication statusPublished - Nov 1998


ASJC Scopus subject areas

  • Organic Chemistry

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