Childhood-onset epilepsy associated with polymicrogyria

Yoko Ohtsuka, Akio Tanaka, Katsuhiro Kobayashi, Hodaka Ohta, Kiyoko Abiru, Kohsuke Nakano, Eiji Oka

Research output: Contribution to journalArticle

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Abstract

To study the electroclinical characteristics of patients with childhood-onset epilepsy who showed polymicrogyria (PMG) on MRI, we classified 15 patients according to the location of PMG on MRI. The composition of the subjects was as follows: four patients with PMG in both hemispheres; three with localized PMG in one hemisphere associated with other lesions such as porencephaly; and eight with only localized PMG in one hemisphere. We investigated the electroclinical characteristics of the epileptic syndromes associated with these different types of PMG. Four patients suffered from infantile spasms during their clinical course. Five patients suffered from epilepsy with electrical status epilepticus during slow sleep (ESES) and ESES-related epilepsy. The other six patients had only localization-related epilepsy throughout their clinical course. Patients with PMG in both hemispheres, and localized PMG in one hemisphere associated with other lesions tended to have early-onset intractable seizures, especially infantile spasms. On the other hand, patients with only localized PMG in one hemisphere had ESES and ESES-related epilepsy or localization-related epilepsy, and their seizure prognosis was relatively favorable. These findings are useful in predicting the outcome of patients with PMG.

Original languageEnglish
Pages (from-to)758-765
Number of pages8
JournalBrain and Development
Volume24
Issue number8
DOIs
Publication statusPublished - Dec 2002

Fingerprint

Epilepsy
Status Epilepticus
Sleep
Infantile Spasms
Partial Epilepsy
Seizures
Polymicrogyria

Keywords

  • Cortical malformation
  • Epilepsy with continuous spike-waves during slow wave sleep
  • Epileptic spasms
  • Infantile spasms
  • Polymicrogyria
  • Prognosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Ohtsuka, Y., Tanaka, A., Kobayashi, K., Ohta, H., Abiru, K., Nakano, K., & Oka, E. (2002). Childhood-onset epilepsy associated with polymicrogyria. Brain and Development, 24(8), 758-765. https://doi.org/10.1016/S0387-7604(02)00099-2

Childhood-onset epilepsy associated with polymicrogyria. / Ohtsuka, Yoko; Tanaka, Akio; Kobayashi, Katsuhiro; Ohta, Hodaka; Abiru, Kiyoko; Nakano, Kohsuke; Oka, Eiji.

In: Brain and Development, Vol. 24, No. 8, 12.2002, p. 758-765.

Research output: Contribution to journalArticle

Ohtsuka, Y, Tanaka, A, Kobayashi, K, Ohta, H, Abiru, K, Nakano, K & Oka, E 2002, 'Childhood-onset epilepsy associated with polymicrogyria', Brain and Development, vol. 24, no. 8, pp. 758-765. https://doi.org/10.1016/S0387-7604(02)00099-2
Ohtsuka, Yoko ; Tanaka, Akio ; Kobayashi, Katsuhiro ; Ohta, Hodaka ; Abiru, Kiyoko ; Nakano, Kohsuke ; Oka, Eiji. / Childhood-onset epilepsy associated with polymicrogyria. In: Brain and Development. 2002 ; Vol. 24, No. 8. pp. 758-765.
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