Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22)

Nozomu Kawashima, Akira Shimada, Takeshi Taketani, Yasuhide Hayashi, Nao Yoshida, Kimikazu Matsumoto, Yoshiyuki Takahashi, Seiji Kojima, Koji Kato

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Acute myeloid leukemia with abnormal bone marrow eosinophilia (AML-M4Eo) is often reported in core binding factor (CBF) leukemia, with translocations such as inv(16)(p13q22), t(16;16)(p13;q22) or t(8;21)(q22;q22); however, it is rarely reported with t(16;21)(q24;q22), which produces the RUNX1-CBFA2T3 (AML1-MTG16) chimera. The similarity between this chimera and RUNX1-RUNXT1 (AML1-MTG8) by t(8;21)(q22;q22) remains controversial. Adult leukemia with t(16;21)(q24;q22) was primarily therapy related, and shows poor prognosis; however, pediatric AML with this translocation was quite rare and tended to be de novo AML. We present here a 4-year-old boy with de novo AML-M4Eo and t(16;21) (q24;q22). He received chemotherapy and survived for more than 70 months without transplantation. We speculated that pediatric AML with t(16;21)(q24;q22) showed favorable prognosis, as with t(8;21)(q22;q22).

Original languageEnglish
Pages (from-to)577-580
Number of pages4
JournalInternational Journal of Hematology
Volume95
Issue number5
DOIs
Publication statusPublished - May 2012
Externally publishedYes

Fingerprint

Eosinophilia
Acute Myeloid Leukemia
Leukemia
Core Binding Factors
Bone Marrow
Pediatrics
Transplantation
Drug Therapy
Therapeutics

Keywords

  • AML
  • Eosinophilia
  • Pediatric
  • RUNX1-CBFA2T3
  • t(16;21)(q24;q22)

ASJC Scopus subject areas

  • Hematology

Cite this

Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22). / Kawashima, Nozomu; Shimada, Akira; Taketani, Takeshi; Hayashi, Yasuhide; Yoshida, Nao; Matsumoto, Kimikazu; Takahashi, Yoshiyuki; Kojima, Seiji; Kato, Koji.

In: International Journal of Hematology, Vol. 95, No. 5, 05.2012, p. 577-580.

Research output: Contribution to journalArticle

Kawashima, N, Shimada, A, Taketani, T, Hayashi, Y, Yoshida, N, Matsumoto, K, Takahashi, Y, Kojima, S & Kato, K 2012, 'Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22)', International Journal of Hematology, vol. 95, no. 5, pp. 577-580. https://doi.org/10.1007/s12185-012-1044-7
Kawashima, Nozomu ; Shimada, Akira ; Taketani, Takeshi ; Hayashi, Yasuhide ; Yoshida, Nao ; Matsumoto, Kimikazu ; Takahashi, Yoshiyuki ; Kojima, Seiji ; Kato, Koji. / Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22). In: International Journal of Hematology. 2012 ; Vol. 95, No. 5. pp. 577-580.
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