Chief cell hyperplasia with structural and nuclear atypia: A variant of fundic gland polyp

Akihiro Matsukawa, Ryoichi Kurano, Takahiro Takemoto, Motoko Kagayama, Takaaki Ito

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11 Citations (Scopus)


A case of an unusual variant of fundic gland polyp (FGP) composed of chief cell hyperplasia with structural and nuclear atypia in an 87-year-old woman is presented. Gastrointestinal endoscopy revealed a sessile polyp in the cardia/corpus transition zone and a polypoid lesion in the fundus. Histologically, the polyp in the cardia/corpus showed a typical appearance of FGP, while that in fundus demonstrated a tumorous lesion composed of irregular branched tubules with nuclear stratification. Despite the structural distortion and nuclear atypia, mitotic figures were absent and MIB-1 positive cells were less than 3%. Immunohistochemically, the cytoplasms of the tubules were negative for gastric mucin and Muc-5AC glycoprotein, but mostly positive for pepsinogen-I, indicating that the proliferated glands consisted mainly of chief cells, not mucous cells. Parietal cells were occasionally found in the glands. At the periphery of the lesion, microcysts composed of parietal cells, chief cells, and mucous cells had developed. Altogether, the polyp in the fundus was diagnosed as an unusual variant of FGP with chief cell hyperplasia. This FGP should be differentiated from tubular adenocarcinoma. Proliferation of chief cells with occasional parietal cells is critical for the differential diagnosis.

Original languageEnglish
Pages (from-to)817-821
Number of pages5
JournalPathology Research and Practice
Issue number11-12
Publication statusPublished - Feb 22 2005
Externally publishedYes


  • Fundic gland polyp
  • Gastric cancer
  • Structural atypia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology


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