Chest high-resolution CT findings of microscopic polyangiitis

A Japanese first nationwide prospective cohort study

Aika Suzuki, Susumu Sakamoto, Atsuko Kurosaki, Yasuyuki Kurihara, Keita Satoh, Yusuke Usui, Toshihiro Nanki, Yoshihiro Arimura, Hirofumi Makino, Yasunori Okada, Masayoshi Harigai, Kunihiro Yamagata, Hitoshi Sugiyama, Hiroaki Dobashi, Akihiro Ishizu, Naotake Tsuboi, Joichi Usui, Kenei Sada, Sakae Homma

Research output: Contribution to journalArticle

Abstract

OBJECTIVE. The lung is one of the organs possibly involved in microscopic polyangiitis (MPA), and myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA) is commonly found in patients with MPA. The aim of this study was to assess pulmonary lesions in Japanese patients with MPA. SUBJECTS AND METHODS. This prospective study was based on 144 patients with MPA who were enrolled in the Remission Induction Therapy in Japanese Patients With ANCA-Associated Vasculitis and Rapidly Progressive Glomerulonephritis Study and who underwent chest high-resolution CT (HRCT) imaging at the time of diagnosis during 2011–2014. We reviewed the electronic case report forms of patients with MPA who did and did not have interstitial pneumonia (IP), and the clinical features and laboratory findings of these groups were compared. RESULTS. Abnormal HRCT findings were noted in 134 of the 144 patients (93%). Chest HRCT findings included ground-glass opacity (n = 72; 50%), reticulation (n = 69; 48%), traction bronchiectasis (n = 57; 42%), honeycombing (n = 44; 31%), and emphysema (n = 32; 22%). IP was diagnosed radiologically in 74 patients (51%), 38% of whom had the usual IP (UIP) pattern. Ground-glass opacity, reticulation, traction bronchiectasis, honeycombing, and interlobular septal thickening were frequent in patients with IP (p < 0.05). Patients with MPA with the UIP or possible UIP pattern also had minor findings, such as bronchial wall thickening, consolidation, increased attenuation around honeycombing, and traction bronchiectasis. CONCLUSION. IP (51%) was most commonly observed in Japanese patients with MPA, and 38% of these patients exhibited a UIP pattern. Increased attenuation around honeycombing or traction bronchiectasis was also found.

Original languageEnglish
Pages (from-to)104-114
Number of pages11
JournalAmerican Journal of Roentgenology
Volume213
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

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Microscopic Polyangiitis
Cohort Studies
Thorax
Prospective Studies
Bronchiectasis
Interstitial Lung Diseases
Traction
Antineutrophil Cytoplasmic Antibodies
Glass
Remission Induction
Lung
Idiopathic Pulmonary Fibrosis
Emphysema
Glomerulonephritis
Vasculitis
Peroxidase

Keywords

  • High-resolution CT
  • Interstitial pneumonia
  • Microscopic polyangiitis
  • Pulmonary lesion
  • Usual interstitial pneumonia pattern

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Chest high-resolution CT findings of microscopic polyangiitis : A Japanese first nationwide prospective cohort study. / Suzuki, Aika; Sakamoto, Susumu; Kurosaki, Atsuko; Kurihara, Yasuyuki; Satoh, Keita; Usui, Yusuke; Nanki, Toshihiro; Arimura, Yoshihiro; Makino, Hirofumi; Okada, Yasunori; Harigai, Masayoshi; Yamagata, Kunihiro; Sugiyama, Hitoshi; Dobashi, Hiroaki; Ishizu, Akihiro; Tsuboi, Naotake; Usui, Joichi; Sada, Kenei; Homma, Sakae.

In: American Journal of Roentgenology, Vol. 213, No. 1, 01.01.2019, p. 104-114.

Research output: Contribution to journalArticle

Suzuki, A, Sakamoto, S, Kurosaki, A, Kurihara, Y, Satoh, K, Usui, Y, Nanki, T, Arimura, Y, Makino, H, Okada, Y, Harigai, M, Yamagata, K, Sugiyama, H, Dobashi, H, Ishizu, A, Tsuboi, N, Usui, J, Sada, K & Homma, S 2019, 'Chest high-resolution CT findings of microscopic polyangiitis: A Japanese first nationwide prospective cohort study', American Journal of Roentgenology, vol. 213, no. 1, pp. 104-114. https://doi.org/10.2214/AJR.18.20967
Suzuki, Aika ; Sakamoto, Susumu ; Kurosaki, Atsuko ; Kurihara, Yasuyuki ; Satoh, Keita ; Usui, Yusuke ; Nanki, Toshihiro ; Arimura, Yoshihiro ; Makino, Hirofumi ; Okada, Yasunori ; Harigai, Masayoshi ; Yamagata, Kunihiro ; Sugiyama, Hitoshi ; Dobashi, Hiroaki ; Ishizu, Akihiro ; Tsuboi, Naotake ; Usui, Joichi ; Sada, Kenei ; Homma, Sakae. / Chest high-resolution CT findings of microscopic polyangiitis : A Japanese first nationwide prospective cohort study. In: American Journal of Roentgenology. 2019 ; Vol. 213, No. 1. pp. 104-114.
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abstract = "OBJECTIVE. The lung is one of the organs possibly involved in microscopic polyangiitis (MPA), and myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA) is commonly found in patients with MPA. The aim of this study was to assess pulmonary lesions in Japanese patients with MPA. SUBJECTS AND METHODS. This prospective study was based on 144 patients with MPA who were enrolled in the Remission Induction Therapy in Japanese Patients With ANCA-Associated Vasculitis and Rapidly Progressive Glomerulonephritis Study and who underwent chest high-resolution CT (HRCT) imaging at the time of diagnosis during 2011–2014. We reviewed the electronic case report forms of patients with MPA who did and did not have interstitial pneumonia (IP), and the clinical features and laboratory findings of these groups were compared. RESULTS. Abnormal HRCT findings were noted in 134 of the 144 patients (93{\%}). Chest HRCT findings included ground-glass opacity (n = 72; 50{\%}), reticulation (n = 69; 48{\%}), traction bronchiectasis (n = 57; 42{\%}), honeycombing (n = 44; 31{\%}), and emphysema (n = 32; 22{\%}). IP was diagnosed radiologically in 74 patients (51{\%}), 38{\%} of whom had the usual IP (UIP) pattern. Ground-glass opacity, reticulation, traction bronchiectasis, honeycombing, and interlobular septal thickening were frequent in patients with IP (p < 0.05). Patients with MPA with the UIP or possible UIP pattern also had minor findings, such as bronchial wall thickening, consolidation, increased attenuation around honeycombing, and traction bronchiectasis. CONCLUSION. IP (51{\%}) was most commonly observed in Japanese patients with MPA, and 38{\%} of these patients exhibited a UIP pattern. Increased attenuation around honeycombing or traction bronchiectasis was also found.",
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T2 - A Japanese first nationwide prospective cohort study

AU - Suzuki, Aika

AU - Sakamoto, Susumu

AU - Kurosaki, Atsuko

AU - Kurihara, Yasuyuki

AU - Satoh, Keita

AU - Usui, Yusuke

AU - Nanki, Toshihiro

AU - Arimura, Yoshihiro

AU - Makino, Hirofumi

AU - Okada, Yasunori

AU - Harigai, Masayoshi

AU - Yamagata, Kunihiro

AU - Sugiyama, Hitoshi

AU - Dobashi, Hiroaki

AU - Ishizu, Akihiro

AU - Tsuboi, Naotake

AU - Usui, Joichi

AU - Sada, Kenei

AU - Homma, Sakae

PY - 2019/1/1

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N2 - OBJECTIVE. The lung is one of the organs possibly involved in microscopic polyangiitis (MPA), and myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA) is commonly found in patients with MPA. The aim of this study was to assess pulmonary lesions in Japanese patients with MPA. SUBJECTS AND METHODS. This prospective study was based on 144 patients with MPA who were enrolled in the Remission Induction Therapy in Japanese Patients With ANCA-Associated Vasculitis and Rapidly Progressive Glomerulonephritis Study and who underwent chest high-resolution CT (HRCT) imaging at the time of diagnosis during 2011–2014. We reviewed the electronic case report forms of patients with MPA who did and did not have interstitial pneumonia (IP), and the clinical features and laboratory findings of these groups were compared. RESULTS. Abnormal HRCT findings were noted in 134 of the 144 patients (93%). Chest HRCT findings included ground-glass opacity (n = 72; 50%), reticulation (n = 69; 48%), traction bronchiectasis (n = 57; 42%), honeycombing (n = 44; 31%), and emphysema (n = 32; 22%). IP was diagnosed radiologically in 74 patients (51%), 38% of whom had the usual IP (UIP) pattern. Ground-glass opacity, reticulation, traction bronchiectasis, honeycombing, and interlobular septal thickening were frequent in patients with IP (p < 0.05). Patients with MPA with the UIP or possible UIP pattern also had minor findings, such as bronchial wall thickening, consolidation, increased attenuation around honeycombing, and traction bronchiectasis. CONCLUSION. IP (51%) was most commonly observed in Japanese patients with MPA, and 38% of these patients exhibited a UIP pattern. Increased attenuation around honeycombing or traction bronchiectasis was also found.

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