Chemotherapy for high-risk early-stage endometrial cancer

Junichi Kodama, Noriko Seki, Yuji Hiramatsu

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


PURPOSE OF REVIEW: To discuss the usefulness of chemotherapy in high-risk early-stage endometrial cancer and the best chemotherapy regimen. RECENT FINDINGS: External radiation therapy has been successfully used to prevent local recurrence; however, it does not improve the overall survival and it increases the incidence of late toxicity. A recent randomized study revealed that adjuvant platinum-based combination chemotherapy might be a suitable alternative to radiotherapy for high-risk early-stage endometrial cancer. The optimal regimen is still in question because combinations of doxorubicin-cisplatin and paclitaxel-doxorubicin-cisplatin cause significant toxicity. The combination of paclitaxel-carboplatin may be better than doxorubicin-cisplatin with regard to toxicities. SUMMARY: Radiation treatment following surgery has been the standard adjuvant therapy for endometrial cancer for a long time. Radiotherapy decreases the local recurrence rates; however, a significant impact on the overall survival has not been demonstrated. The usefulness of adjuvant chemotherapy has been demonstrated by only a little evidence. Nonetheless, we are encouraged by a recent randomized study. In light of the excellent outcomes associated with early-stage endometrial cancer, it is important to conduct another large randomized trial based on standardization of high-risk criteria to evaluate the efficacy of adjuvant chemotherapy.

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalCurrent Opinion in Obstetrics and Gynecology
Issue number1
Publication statusPublished - Feb 2007
Externally publishedYes


  • Chemotherapy
  • Early stage
  • Endometrial cancer
  • Radiotherapy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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