Chemotherapeutic results for elderly acute leukemia

M. Takeuchi, A. Kuyama, Hideki Katayama, N. Horita, M. Horiba, A. Tamaoki, C. Okada, A. Tada, S. Kawahara, Y. Mishima, R. Soda, K. Takahashi

Research output: Contribution to journalArticle

Abstract

Chemotherapeutic results of 25 elderly patients with acute leukemia (65 - 83 year-old, median 71 y.o, FAB classification; M0 : 3, M1 : 6, M2 : 4, M3 : 1, M4 : 5, M6 : 1, L2 : 4, L3 : 1 cases) were analysed. Although overall complete remission (CR) rate was 75.0%, 50% survival and 3-year survival rate was significantly poor compared with those of younger leukemia patients (12.0 M vs 41.1 M, 19.3% vs 56.5%). Significant differences in disease free survival (DFS) and overall survival (OS) were found between patients who achieved CR after one course of induction therapy and who achieved CR after two or more courses (50% DFS : 3.7 M vs 9.2 M, 50% OS : 9.7 M vs 34.2 M). Chemotherapeutic results of elderly acute leukemia were poor despite intensive chemotherapy. Large scale, multi-center studies are needed to establish therapeutic strategy for elderly acute leukemia.

Original languageEnglish
Pages (from-to)583-587
Number of pages5
JournalIRYO - Japanese Journal of National Medical Services
Volume53
Issue number9
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Leukemia
Disease-Free Survival
Survival
Survival Rate
Drug Therapy
Therapeutics

Keywords

  • Acute leukemia
  • Chemotherapy
  • Elderly patient

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Takeuchi, M., Kuyama, A., Katayama, H., Horita, N., Horiba, M., Tamaoki, A., ... Takahashi, K. (1999). Chemotherapeutic results for elderly acute leukemia. IRYO - Japanese Journal of National Medical Services, 53(9), 583-587.

Chemotherapeutic results for elderly acute leukemia. / Takeuchi, M.; Kuyama, A.; Katayama, Hideki; Horita, N.; Horiba, M.; Tamaoki, A.; Okada, C.; Tada, A.; Kawahara, S.; Mishima, Y.; Soda, R.; Takahashi, K.

In: IRYO - Japanese Journal of National Medical Services, Vol. 53, No. 9, 1999, p. 583-587.

Research output: Contribution to journalArticle

Takeuchi, M, Kuyama, A, Katayama, H, Horita, N, Horiba, M, Tamaoki, A, Okada, C, Tada, A, Kawahara, S, Mishima, Y, Soda, R & Takahashi, K 1999, 'Chemotherapeutic results for elderly acute leukemia', IRYO - Japanese Journal of National Medical Services, vol. 53, no. 9, pp. 583-587.
Takeuchi M, Kuyama A, Katayama H, Horita N, Horiba M, Tamaoki A et al. Chemotherapeutic results for elderly acute leukemia. IRYO - Japanese Journal of National Medical Services. 1999;53(9):583-587.
Takeuchi, M. ; Kuyama, A. ; Katayama, Hideki ; Horita, N. ; Horiba, M. ; Tamaoki, A. ; Okada, C. ; Tada, A. ; Kawahara, S. ; Mishima, Y. ; Soda, R. ; Takahashi, K. / Chemotherapeutic results for elderly acute leukemia. In: IRYO - Japanese Journal of National Medical Services. 1999 ; Vol. 53, No. 9. pp. 583-587.
@article{8ea842dd331b4d03b0777633fe73d3f6,
title = "Chemotherapeutic results for elderly acute leukemia",
abstract = "Chemotherapeutic results of 25 elderly patients with acute leukemia (65 - 83 year-old, median 71 y.o, FAB classification; M0 : 3, M1 : 6, M2 : 4, M3 : 1, M4 : 5, M6 : 1, L2 : 4, L3 : 1 cases) were analysed. Although overall complete remission (CR) rate was 75.0{\%}, 50{\%} survival and 3-year survival rate was significantly poor compared with those of younger leukemia patients (12.0 M vs 41.1 M, 19.3{\%} vs 56.5{\%}). Significant differences in disease free survival (DFS) and overall survival (OS) were found between patients who achieved CR after one course of induction therapy and who achieved CR after two or more courses (50{\%} DFS : 3.7 M vs 9.2 M, 50{\%} OS : 9.7 M vs 34.2 M). Chemotherapeutic results of elderly acute leukemia were poor despite intensive chemotherapy. Large scale, multi-center studies are needed to establish therapeutic strategy for elderly acute leukemia.",
keywords = "Acute leukemia, Chemotherapy, Elderly patient",
author = "M. Takeuchi and A. Kuyama and Hideki Katayama and N. Horita and M. Horiba and A. Tamaoki and C. Okada and A. Tada and S. Kawahara and Y. Mishima and R. Soda and K. Takahashi",
year = "1999",
language = "English",
volume = "53",
pages = "583--587",
journal = "IRYO - Japanese Journal of National Medical Services",
issn = "0021-1699",
publisher = "Japanese Society of National Medical Services",
number = "9",

}

TY - JOUR

T1 - Chemotherapeutic results for elderly acute leukemia

AU - Takeuchi, M.

AU - Kuyama, A.

AU - Katayama, Hideki

AU - Horita, N.

AU - Horiba, M.

AU - Tamaoki, A.

AU - Okada, C.

AU - Tada, A.

AU - Kawahara, S.

AU - Mishima, Y.

AU - Soda, R.

AU - Takahashi, K.

PY - 1999

Y1 - 1999

N2 - Chemotherapeutic results of 25 elderly patients with acute leukemia (65 - 83 year-old, median 71 y.o, FAB classification; M0 : 3, M1 : 6, M2 : 4, M3 : 1, M4 : 5, M6 : 1, L2 : 4, L3 : 1 cases) were analysed. Although overall complete remission (CR) rate was 75.0%, 50% survival and 3-year survival rate was significantly poor compared with those of younger leukemia patients (12.0 M vs 41.1 M, 19.3% vs 56.5%). Significant differences in disease free survival (DFS) and overall survival (OS) were found between patients who achieved CR after one course of induction therapy and who achieved CR after two or more courses (50% DFS : 3.7 M vs 9.2 M, 50% OS : 9.7 M vs 34.2 M). Chemotherapeutic results of elderly acute leukemia were poor despite intensive chemotherapy. Large scale, multi-center studies are needed to establish therapeutic strategy for elderly acute leukemia.

AB - Chemotherapeutic results of 25 elderly patients with acute leukemia (65 - 83 year-old, median 71 y.o, FAB classification; M0 : 3, M1 : 6, M2 : 4, M3 : 1, M4 : 5, M6 : 1, L2 : 4, L3 : 1 cases) were analysed. Although overall complete remission (CR) rate was 75.0%, 50% survival and 3-year survival rate was significantly poor compared with those of younger leukemia patients (12.0 M vs 41.1 M, 19.3% vs 56.5%). Significant differences in disease free survival (DFS) and overall survival (OS) were found between patients who achieved CR after one course of induction therapy and who achieved CR after two or more courses (50% DFS : 3.7 M vs 9.2 M, 50% OS : 9.7 M vs 34.2 M). Chemotherapeutic results of elderly acute leukemia were poor despite intensive chemotherapy. Large scale, multi-center studies are needed to establish therapeutic strategy for elderly acute leukemia.

KW - Acute leukemia

KW - Chemotherapy

KW - Elderly patient

UR - http://www.scopus.com/inward/record.url?scp=0032755639&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032755639&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032755639

VL - 53

SP - 583

EP - 587

JO - IRYO - Japanese Journal of National Medical Services

JF - IRYO - Japanese Journal of National Medical Services

SN - 0021-1699

IS - 9

ER -