Chemotherapeutic results for elderly acute leukemia

M. Takeuchi, A. Kuyama, H. Katayama, N. Horita, M. Horiba, A. Tamaoki, C. Okada, A. Tada, S. Kawahara, Y. Mishima, R. Soda, K. Takahashi

Research output: Contribution to journalArticle

Abstract

Chemotherapeutic results of 25 elderly patients with acute leukemia (65 - 83 year-old, median 71 y.o, FAB classification; M0 : 3, M1 : 6, M2 : 4, M3 : 1, M4 : 5, M6 : 1, L2 : 4, L3 : 1 cases) were analysed. Although overall complete remission (CR) rate was 75.0%, 50% survival and 3-year survival rate was significantly poor compared with those of younger leukemia patients (12.0 M vs 41.1 M, 19.3% vs 56.5%). Significant differences in disease free survival (DFS) and overall survival (OS) were found between patients who achieved CR after one course of induction therapy and who achieved CR after two or more courses (50% DFS : 3.7 M vs 9.2 M, 50% OS : 9.7 M vs 34.2 M). Chemotherapeutic results of elderly acute leukemia were poor despite intensive chemotherapy. Large scale, multi-center studies are needed to establish therapeutic strategy for elderly acute leukemia.

Original languageEnglish
Pages (from-to)583-587
Number of pages5
JournalIRYO - Japanese Journal of National Medical Services
Volume53
Issue number9
Publication statusPublished - Jan 1 1999

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Keywords

  • Acute leukemia
  • Chemotherapy
  • Elderly patient

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Takeuchi, M., Kuyama, A., Katayama, H., Horita, N., Horiba, M., Tamaoki, A., Okada, C., Tada, A., Kawahara, S., Mishima, Y., Soda, R., & Takahashi, K. (1999). Chemotherapeutic results for elderly acute leukemia. IRYO - Japanese Journal of National Medical Services, 53(9), 583-587.