Abstract
Chemotherapeutic results of 25 elderly patients with acute leukemia (65 - 83 year-old, median 71 y.o, FAB classification; M0 : 3, M1 : 6, M2 : 4, M3 : 1, M4 : 5, M6 : 1, L2 : 4, L3 : 1 cases) were analysed. Although overall complete remission (CR) rate was 75.0%, 50% survival and 3-year survival rate was significantly poor compared with those of younger leukemia patients (12.0 M vs 41.1 M, 19.3% vs 56.5%). Significant differences in disease free survival (DFS) and overall survival (OS) were found between patients who achieved CR after one course of induction therapy and who achieved CR after two or more courses (50% DFS : 3.7 M vs 9.2 M, 50% OS : 9.7 M vs 34.2 M). Chemotherapeutic results of elderly acute leukemia were poor despite intensive chemotherapy. Large scale, multi-center studies are needed to establish therapeutic strategy for elderly acute leukemia.
| Original language | English |
|---|---|
| Pages (from-to) | 583-587 |
| Number of pages | 5 |
| Journal | IRYO - Japanese Journal of National Medical Services |
| Volume | 53 |
| Issue number | 9 |
| Publication status | Published - 1999 |
| Externally published | Yes |
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Keywords
- Acute leukemia
- Chemotherapy
- Elderly patient
ASJC Scopus subject areas
- Medicine(all)
Cite this
Chemotherapeutic results for elderly acute leukemia. / Takeuchi, M.; Kuyama, A.; Katayama, Hideki; Horita, N.; Horiba, M.; Tamaoki, A.; Okada, C.; Tada, A.; Kawahara, S.; Mishima, Y.; Soda, R.; Takahashi, K.
In: IRYO - Japanese Journal of National Medical Services, Vol. 53, No. 9, 1999, p. 583-587.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chemotherapeutic results for elderly acute leukemia
AU - Takeuchi, M.
AU - Kuyama, A.
AU - Katayama, Hideki
AU - Horita, N.
AU - Horiba, M.
AU - Tamaoki, A.
AU - Okada, C.
AU - Tada, A.
AU - Kawahara, S.
AU - Mishima, Y.
AU - Soda, R.
AU - Takahashi, K.
PY - 1999
Y1 - 1999
N2 - Chemotherapeutic results of 25 elderly patients with acute leukemia (65 - 83 year-old, median 71 y.o, FAB classification; M0 : 3, M1 : 6, M2 : 4, M3 : 1, M4 : 5, M6 : 1, L2 : 4, L3 : 1 cases) were analysed. Although overall complete remission (CR) rate was 75.0%, 50% survival and 3-year survival rate was significantly poor compared with those of younger leukemia patients (12.0 M vs 41.1 M, 19.3% vs 56.5%). Significant differences in disease free survival (DFS) and overall survival (OS) were found between patients who achieved CR after one course of induction therapy and who achieved CR after two or more courses (50% DFS : 3.7 M vs 9.2 M, 50% OS : 9.7 M vs 34.2 M). Chemotherapeutic results of elderly acute leukemia were poor despite intensive chemotherapy. Large scale, multi-center studies are needed to establish therapeutic strategy for elderly acute leukemia.
AB - Chemotherapeutic results of 25 elderly patients with acute leukemia (65 - 83 year-old, median 71 y.o, FAB classification; M0 : 3, M1 : 6, M2 : 4, M3 : 1, M4 : 5, M6 : 1, L2 : 4, L3 : 1 cases) were analysed. Although overall complete remission (CR) rate was 75.0%, 50% survival and 3-year survival rate was significantly poor compared with those of younger leukemia patients (12.0 M vs 41.1 M, 19.3% vs 56.5%). Significant differences in disease free survival (DFS) and overall survival (OS) were found between patients who achieved CR after one course of induction therapy and who achieved CR after two or more courses (50% DFS : 3.7 M vs 9.2 M, 50% OS : 9.7 M vs 34.2 M). Chemotherapeutic results of elderly acute leukemia were poor despite intensive chemotherapy. Large scale, multi-center studies are needed to establish therapeutic strategy for elderly acute leukemia.
KW - Acute leukemia
KW - Chemotherapy
KW - Elderly patient
UR - http://www.scopus.com/inward/record.url?scp=0032755639&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032755639&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0032755639
VL - 53
SP - 583
EP - 587
JO - IRYO - Japanese Journal of National Medical Services
JF - IRYO - Japanese Journal of National Medical Services
SN - 0021-1699
IS - 9
ER -