Chemoselective methylenation with a methylenedianion synthon

Takashi Okazoe, Jun ichi Hibino, Kazuhiko Takai, Hitosi Nozakil

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

The combination of CH2I2-ZN-Ti(OiPr)4 or CH2I2-ZN-Me3Al is effective for the selective methylenation of aldehydes. Seletive methylenation of a ketone group is performed by pretreatment of a substrate with Ti(NET2)4.

Original languageEnglish
Pages (from-to)5581-5584
Number of pages4
JournalTetrahedron Letters
Volume26
Issue number45
DOIs
Publication statusPublished - 1985
Externally publishedYes

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Ketones
Aldehydes
Substrates
titanium isopropoxide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Chemoselective methylenation with a methylenedianion synthon. / Okazoe, Takashi; Hibino, Jun ichi; Takai, Kazuhiko; Nozakil, Hitosi.

In: Tetrahedron Letters, Vol. 26, No. 45, 1985, p. 5581-5584.

Research output: Contribution to journalArticle

Okazoe, Takashi ; Hibino, Jun ichi ; Takai, Kazuhiko ; Nozakil, Hitosi. / Chemoselective methylenation with a methylenedianion synthon. In: Tetrahedron Letters. 1985 ; Vol. 26, No. 45. pp. 5581-5584.
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