Chemoselective methylenation with a methylenedianion synthon

Takashi Okazoe, Jun ichi Hibino, Kazuhiko Takai, Hitosi Nozakil

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

The combination of CH2I2-ZN-Ti(OiPr)4 or CH2I2-ZN-Me3Al is effective for the selective methylenation of aldehydes. Seletive methylenation of a ketone group is performed by pretreatment of a substrate with Ti(NET2)4.

Original languageEnglish
Pages (from-to)5581-5584
Number of pages4
JournalTetrahedron Letters
Volume26
Issue number45
DOIs
Publication statusPublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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