Chemoselective methylenation with a methylenedianion synthon

Takashi Okazoe; Jun ichi Hibino; Kazuhiko Takai; Hitosi Nozakil

doi:10.1016/S0040-4039(01)80893-5

Chemoselective methylenation with a methylenedianion synthon

Takashi Okazoe, Jun ichi Hibino, Kazuhiko Takai, Hitosi Nozakil

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

The combination of CH₂I₂-ZN-Ti(OⁱPr)₄ or CH₂I₂-ZN-Me₃Al is effective for the selective methylenation of aldehydes. Seletive methylenation of a ketone group is performed by pretreatment of a substrate with Ti(NET₂)₄.

Original language	English
Pages (from-to)	5581-5584
Number of pages	4
Journal	Tetrahedron Letters
Volume	26
Issue number	45
DOIs	https://doi.org/10.1016/S0040-4039(01)80893-5
Publication status	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Chemoselective methylenation with a methylenedianion synthon",

abstract = "The combination of CH2I2-ZN-Ti(OiPr)4 or CH2I2-ZN-Me3Al is effective for the selective methylenation of aldehydes. Seletive methylenation of a ketone group is performed by pretreatment of a substrate with Ti(NET2)4.",

author = "Takashi Okazoe and Hibino, {Jun ichi} and Kazuhiko Takai and Hitosi Nozakil",

year = "1985",

doi = "10.1016/S0040-4039(01)80893-5",

language = "English",

volume = "26",

pages = "5581--5584",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "45",

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T1 - Chemoselective methylenation with a methylenedianion synthon

AU - Okazoe, Takashi

AU - Hibino, Jun ichi

AU - Takai, Kazuhiko

AU - Nozakil, Hitosi

PY - 1985

Y1 - 1985

N2 - The combination of CH2I2-ZN-Ti(OiPr)4 or CH2I2-ZN-Me3Al is effective for the selective methylenation of aldehydes. Seletive methylenation of a ketone group is performed by pretreatment of a substrate with Ti(NET2)4.

AB - The combination of CH2I2-ZN-Ti(OiPr)4 or CH2I2-ZN-Me3Al is effective for the selective methylenation of aldehydes. Seletive methylenation of a ketone group is performed by pretreatment of a substrate with Ti(NET2)4.

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U2 - 10.1016/S0040-4039(01)80893-5

DO - 10.1016/S0040-4039(01)80893-5

M3 - Article

AN - SCOPUS:0000696819

VL - 26

SP - 5581

EP - 5584

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 45

ER -

Chemoselective methylenation with a methylenedianion synthon

Abstract

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