Chemoselective electrolytic chlorination of methyl group of 3-methyl-3-butenoate moiety of thiazoline-azetidinone homologues

Sigeru Torii, Hideo Tanaka, Norio Saitoh, Takashi Siroi, Michio Sasaoka, Junzo Nokami

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Chemoselective electrochlorination of the methyl group on the 3-methyl-3-butenoate moiety of thiazoline-azetidinone derivatives derived from penicillins G and V has been performed in a CH2Cl2-H2O-NaCl-H2SO4 -(Pt or C electrodes) system by adjusting the amount of electricity passed as well as the concentration of Cl- in the media.

Original languageEnglish
Pages (from-to)3193-3196
Number of pages4
JournalTetrahedron Letters
Volume22
Issue number33
DOIs
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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