Chemoselective electrolytic chlorination of methyl group of 3-methyl-3-butenoate moiety of thiazoline-azetidinone homologues

Sigeru Torii, Hideo Tanaka, Norio Saitoh, Takashi Siroi, Michio Sasaoka, Junzo Nokami

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

Chemoselective electrochlorination of the methyl group on the 3-methyl-3-butenoate moiety of thiazoline-azetidinone derivatives derived from penicillins G and V has been performed in a CH2Cl2-H2O-NaCl-H2SO4 -(Pt or C electrodes) system by adjusting the amount of electricity passed as well as the concentration of Cl- in the media.

Original languageEnglish
Pages (from-to)3193-3196
Number of pages4
JournalTetrahedron Letters
Volume22
Issue number33
DOIs
Publication statusPublished - 1981

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Penicillin V
Electricity
Penicillin G
Chlorination
Halogenation
Electrodes
Derivatives
2-azetidinone

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Chemoselective electrolytic chlorination of methyl group of 3-methyl-3-butenoate moiety of thiazoline-azetidinone homologues. / Torii, Sigeru; Tanaka, Hideo; Saitoh, Norio; Siroi, Takashi; Sasaoka, Michio; Nokami, Junzo.

In: Tetrahedron Letters, Vol. 22, No. 33, 1981, p. 3193-3196.

Research output: Contribution to journal › Article

Torii, S, Tanaka, H, Saitoh, N, Siroi, T, Sasaoka, M & Nokami, J 1981, 'Chemoselective electrolytic chlorination of methyl group of 3-methyl-3-butenoate moiety of thiazoline-azetidinone homologues', Tetrahedron Letters, vol. 22, no. 33, pp. 3193-3196. https://doi.org/10.1016/S0040-4039(01)81861-X
Torii S, Tanaka H, Saitoh N, Siroi T, Sasaoka M, Nokami J. Chemoselective electrolytic chlorination of methyl group of 3-methyl-3-butenoate moiety of thiazoline-azetidinone homologues. Tetrahedron Letters. 1981;22(33):3193-3196. https://doi.org/10.1016/S0040-4039(01)81861-X
Torii, Sigeru ; Tanaka, Hideo ; Saitoh, Norio ; Siroi, Takashi ; Sasaoka, Michio ; Nokami, Junzo. / Chemoselective electrolytic chlorination of methyl group of 3-methyl-3-butenoate moiety of thiazoline-azetidinone homologues. In: Tetrahedron Letters. 1981 ; Vol. 22, No. 33. pp. 3193-3196.
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