Chemokines in homeostasis and diseases

Keqiang Chen, Zhiyao Bao, Peng Tang, Wanghua Gong, Teizo Yoshimura, Ji Ming Wang

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

For the past twenty years, chemokines have emerged as a family of critical mediators of cell migration during immune surveillance, development, inflammation and cancer progression. Chemokines bind to seven transmembrane G protein-coupled receptors (GPCRs) that are expressed by a wide variety of cell types and cause conformational changes in trimeric G proteins that trigger the intracellular signaling pathways necessary for cell movement and activation. Although chemokines have evolved to benefit the host, inappropriate regulation or utilization of these small proteins may contribute to or even cause diseases. Therefore, understanding the role of chemokines and their GPCRs in the complex physiological and diseased microenvironment is important for the identification of novel therapeutic targets. This review introduces the functional array and signals of multiple chemokine GPCRs in guiding leukocyte trafficking as well as their roles in homeostasis, inflammation, immune responses and cancer.

Original languageEnglish
Pages (from-to)324-334
Number of pages11
JournalCellular and Molecular Immunology
Volume15
Issue number4
DOIs
Publication statusPublished - Apr 1 2018

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Keywords

  • Chemokines
  • Chemotaxis
  • Diseases
  • GPCRs
  • Homeostasis
  • Inflammatory cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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