Chemokines and innate immunity

Akihiro Matsukawa, C. M. Hogaboam, N. W. Lukacs, S. L. Kunkel

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Our environment contains a great variety of infectious microbes that may be potentially destructive and threaten our survival. As soon as microbes try to establish a site of infection, the host launches a complex defense system. Innate immunity is a non-specific response and serves as the first-line of defense where phagocytes, such as neutrophils and macrophages, and NK cells play central roles in neutralizing and clearing microorganisms. Thus, migration of cells into infectious foci and subsequent activation of these cells appear to be a critical step, enabling the host to achieve effective and efficient removal of microbes. Over the past decade, chemokines have been identified as chemotactic cytokines that attract and activate specific types of leukocyte populations in vitro. There is now evidence that the magnitude of chemokines' expression in infectious diseases is strongly associated with the severity of the inflammatory responses. Blocking chemokines or their receptors with neutralizing antibodies or gene targeting technology has allowed us to understand the pathological significance of chemokines in animal models of infectious diseases. Growing evidence suggests that chemokines play an important beneficial role in immune system development, homeostasis and in innate immunity, which may pave the way for new therapeutic strategies for the treatment of infectious diseases.

Original languageEnglish
Pages (from-to)339-358
Number of pages20
JournalReviews in Immunogenetics
Volume2
Issue number3
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Chemokines
Innate Immunity
Communicable Diseases
Gene Targeting
Phagocytes
Neutralizing Antibodies
Natural Killer Cells
Cell Movement
Immune System
Neutrophils
Leukocytes
Homeostasis
Animal Models
Macrophages
Technology
Infection
Population

Keywords

  • Chemokine receptors
  • Chemokines
  • Host defense
  • Infection
  • NK cells
  • Phagocytes

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Matsukawa, A., Hogaboam, C. M., Lukacs, N. W., & Kunkel, S. L. (2000). Chemokines and innate immunity. Reviews in Immunogenetics, 2(3), 339-358.

Chemokines and innate immunity. / Matsukawa, Akihiro; Hogaboam, C. M.; Lukacs, N. W.; Kunkel, S. L.

In: Reviews in Immunogenetics, Vol. 2, No. 3, 2000, p. 339-358.

Research output: Contribution to journalArticle

Matsukawa, A, Hogaboam, CM, Lukacs, NW & Kunkel, SL 2000, 'Chemokines and innate immunity', Reviews in Immunogenetics, vol. 2, no. 3, pp. 339-358.
Matsukawa A, Hogaboam CM, Lukacs NW, Kunkel SL. Chemokines and innate immunity. Reviews in Immunogenetics. 2000;2(3):339-358.
Matsukawa, Akihiro ; Hogaboam, C. M. ; Lukacs, N. W. ; Kunkel, S. L. / Chemokines and innate immunity. In: Reviews in Immunogenetics. 2000 ; Vol. 2, No. 3. pp. 339-358.
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