Chemistry of N-chloronortropine derivatives: Synthesis of a bridged aziridine compound and new tropane derivatives

Syuichi Furuya, Toshihiko Okamoto

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

An unsymmetrical bridged aziridine compound was obtained from N-chloronortropinone. This compound was found to react with acyl halides, acid anhydrides, and other reagents, including a Michael acceptor, dimethyl acetylenedicarboxylate (DMAD), giving new tropane bases with a ketone functional group at the bridged ethylene moiety. In the case of Michael-type addition, the retention of the aziridine ring system was observed in some solvents.

Original languageEnglish
Pages (from-to)2609-2618
Number of pages10
JournalHeterocycles
Volume27
Issue number11
DOIs
Publication statusPublished - Nov 1988

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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