Abstract
Chemical modifications of the I287C mutant of a Burkholderia cepacia lipase afforded various I287C-X conjugates, among which I287C-PAA bearing an N-phenylacetamide (PAA) moiety showed excellent enantioselectivity and catalytic activity for secondary alcohols. Site-directed chemical modifications are powerful tools to control enantioselective biocatalysis.
| Original language | English |
|---|---|
| Pages (from-to) | 1374-1376 |
| Number of pages | 3 |
| Journal | Chemistry Letters |
| Volume | 44 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Jan 1 2015 |
ASJC Scopus subject areas
- Chemistry(all)
Fingerprint Dive into the research topics of 'Chemical modification of lipase for rational enhancement of enantioselectivity'. Together they form a unique fingerprint.
Cite this
Ema, T., & Inoue, H. (2015). Chemical modification of lipase for rational enhancement of enantioselectivity. Chemistry Letters, 44(10), 1374-1376. https://doi.org/10.1246/cl.150667