Abstract
An aconite alkaloid, kobusine (1) was converted to a C14-C20 bond cleaved derivative (12) by a novel fragmentation reaction via a chloramine (11). Possible mechanisms were discussed in which participation of anionic nitrogen was proposed. The C14-C20 bond regeneration in compound (12) was also accomplished by an intramolecular Grignard type reaction.
Original language | English |
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Pages (from-to) | 3199-3207 |
Number of pages | 9 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 26 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1978 |
Externally published | Yes |
Keywords
- aconitum
- chloramine
- diterpene alkaloid
- fragmentation reaction
- intramolecular Grignard reaction
- kobusine
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery