An aconite alkaloid, kobusine (1) was converted to a C14-C20 bond cleaved derivative (12) by a novel fragmentation reaction via a chloramine (11). Possible mechanisms were discussed in which participation of anionic nitrogen was proposed. The C14-C20 bond regeneration in compound (12) was also accomplished by an intramolecular Grignard type reaction.
- diterpene alkaloid
- fragmentation reaction
- intramolecular Grignard reaction
ASJC Scopus subject areas
- Drug Discovery