Abstract
Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin enhances inflammation. Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory properties, chemerin may be involved in both the initiation and resolution of inflammation.
| Original language | English |
|---|---|
| Pages (from-to) | 2187-2190 |
| Number of pages | 4 |
| Journal | Journal of Experimental Medicine |
| Volume | 205 |
| Issue number | 10 |
| DOIs |
|
| Publication status | Published - Sep 29 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Chemerin reveals its chimeric nature. / Yoshimura, Teizo; Oppenheim, Joost J.
In: Journal of Experimental Medicine, Vol. 205, No. 10, 29.09.2008, p. 2187-2190.Research output: Contribution to journal › Comment/debate
}
TY - JOUR
T1 - Chemerin reveals its chimeric nature
AU - Yoshimura, Teizo
AU - Oppenheim, Joost J.
PY - 2008/9/29
Y1 - 2008/9/29
N2 - Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin enhances inflammation. Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory properties, chemerin may be involved in both the initiation and resolution of inflammation.
AB - Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin enhances inflammation. Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory properties, chemerin may be involved in both the initiation and resolution of inflammation.
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UR - http://www.scopus.com/inward/citedby.url?scp=53349120340&partnerID=8YFLogxK
U2 - 10.1084/jem.20081736
DO - 10.1084/jem.20081736
M3 - Comment/debate
C2 - 18809717
AN - SCOPUS:53349120340
VL - 205
SP - 2187
EP - 2190
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
SN - 0022-1007
IS - 10
ER -