Chemerin reveals its chimeric nature

Teizo Yoshimura, Joost J. Oppenheim

Research output: Contribution to journalComment/debate

74 Citations (Scopus)

Abstract

Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin enhances inflammation. Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory properties, chemerin may be involved in both the initiation and resolution of inflammation.

Original languageEnglish
Pages (from-to)2187-2190
Number of pages4
JournalJournal of Experimental Medicine
Volume205
Issue number10
DOIs
Publication statusPublished - Sep 29 2008
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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