Chemerin reveals its chimeric nature

Teizo Yoshimura; Joost J. Oppenheim

doi:10.1084/jem.20081736

Chemerin reveals its chimeric nature

Teizo Yoshimura, Joost J. Oppenheim

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Comment/debate › peer-review

74 Citations (Scopus)

Abstract

Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin enhances inflammation. Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory properties, chemerin may be involved in both the initiation and resolution of inflammation.

Original language	English
Pages (from-to)	2187-2190
Number of pages	4
Journal	Journal of Experimental Medicine
Volume	205
Issue number	10
DOIs	https://doi.org/10.1084/jem.20081736
Publication status	Published - Sep 29 2008

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1084/jem.20081736

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