Chemerin reveals its chimeric nature

Teizo Yoshimura, Joost J. Oppenheim

Research output: Contribution to journalComment/debate

72 Citations (Scopus)

Abstract

Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin enhances inflammation. Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory properties, chemerin may be involved in both the initiation and resolution of inflammation.

Original languageEnglish
Pages (from-to)2187-2190
Number of pages4
JournalJournal of Experimental Medicine
Volume205
Issue number10
DOIs
Publication statusPublished - Sep 29 2008
Externally publishedYes

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Inflammation
Chemotaxis
Dendritic Cells
Blood Proteins
Anti-Inflammatory Agents
Macrophages
Peptides

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Chemerin reveals its chimeric nature. / Yoshimura, Teizo; Oppenheim, Joost J.

In: Journal of Experimental Medicine, Vol. 205, No. 10, 29.09.2008, p. 2187-2190.

Research output: Contribution to journalComment/debate

Yoshimura, Teizo ; Oppenheim, Joost J. / Chemerin reveals its chimeric nature. In: Journal of Experimental Medicine. 2008 ; Vol. 205, No. 10. pp. 2187-2190.
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