Abstract
Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin enhances inflammation. Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory properties, chemerin may be involved in both the initiation and resolution of inflammation.
Original language | English |
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Pages (from-to) | 2187-2190 |
Number of pages | 4 |
Journal | Journal of Experimental Medicine |
Volume | 205 |
Issue number | 10 |
DOIs |
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Publication status | Published - Sep 29 2008 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology