Characterization of the transcriptional initiation regions of genes for the major secreted protein antigens 85C and MPB51 of Mycobacterium bovis BCG

Naoya Ohara; Takeshi Nishiyama; Naoko Ohara-Wada; Sohkichi Matsumoto; Takemitsu Matsuo; Takeshi Yamada

doi:10.1006/mpat.1997.0159

Characterization of the transcriptional initiation regions of genes for the major secreted protein antigens 85C and MPB51 of Mycobacterium bovis BCG

Naoya Ohara, Takeshi Nishiyama, Naoko Ohara-Wada, Sohkichi Matsumoto, Takemitsu Matsuo, Takeshi Yamada

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The component of mycobacterial 85 Complex (85A, 85B, and 85C) and MPB51 are very important from immunological, biochemicaL, and antimycobacterial points of view. In this study, the transcriptional properties of genes encoding three components of 85 complex and MPB51 from BCG were analysed. The authors' analyses revealed that genes for 85A and MPB51 were transcribed as a single unit despite the one operon-like structure and these four genes were probably under a different regulatory control. These findings may help to understand the immunological and physiological roles of these antigens.

Original language	English
Pages (from-to)	303-310
Number of pages	8
Journal	Microbial Pathogenesis
Volume	23
Issue number	5
DOIs	https://doi.org/10.1006/mpat.1997.0159
Publication status	Published - Nov 1997
Externally published	Yes

Keywords

85 complex
Mycobacterium bovis BCG
mRNA analysis
transcription
α antigen

ASJC Scopus subject areas

Microbiology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1006/mpat.1997.0159

Cite this

Characterization of the transcriptional initiation regions of genes for the major secreted protein antigens 85C and MPB51 of Mycobacterium bovis BCG. / Ohara, Naoya; Nishiyama, Takeshi; Ohara-Wada, Naoko; Matsumoto, Sohkichi; Matsuo, Takemitsu; Yamada, Takeshi.

In: Microbial Pathogenesis, Vol. 23, No. 5, 11.1997, p. 303-310.

Research output: Contribution to journal › Article › peer-review

@article{c182ee6dfc6a4397a0017d2fe9f05c91,

title = "Characterization of the transcriptional initiation regions of genes for the major secreted protein antigens 85C and MPB51 of Mycobacterium bovis BCG",

abstract = "The component of mycobacterial 85 Complex (85A, 85B, and 85C) and MPB51 are very important from immunological, biochemicaL, and antimycobacterial points of view. In this study, the transcriptional properties of genes encoding three components of 85 complex and MPB51 from BCG were analysed. The authors' analyses revealed that genes for 85A and MPB51 were transcribed as a single unit despite the one operon-like structure and these four genes were probably under a different regulatory control. These findings may help to understand the immunological and physiological roles of these antigens.",

keywords = "85 complex, Mycobacterium bovis BCG, mRNA analysis, transcription, α antigen",

author = "Naoya Ohara and Takeshi Nishiyama and Naoko Ohara-Wada and Sohkichi Matsumoto and Takemitsu Matsuo and Takeshi Yamada",

note = "Funding Information: This work was partly supported by grants from the U.S. Japan Cooperative Medical Science Program.",

year = "1997",

month = nov,

doi = "10.1006/mpat.1997.0159",

language = "English",

volume = "23",

pages = "303--310",

journal = "Microbial Pathogenesis",

issn = "0882-4010",

publisher = "Academic Press Inc.",

number = "5",

}

TY - JOUR

T1 - Characterization of the transcriptional initiation regions of genes for the major secreted protein antigens 85C and MPB51 of Mycobacterium bovis BCG

AU - Ohara, Naoya

AU - Nishiyama, Takeshi

AU - Ohara-Wada, Naoko

AU - Matsumoto, Sohkichi

AU - Matsuo, Takemitsu

AU - Yamada, Takeshi

N1 - Funding Information: This work was partly supported by grants from the U.S. Japan Cooperative Medical Science Program.

PY - 1997/11

Y1 - 1997/11

N2 - The component of mycobacterial 85 Complex (85A, 85B, and 85C) and MPB51 are very important from immunological, biochemicaL, and antimycobacterial points of view. In this study, the transcriptional properties of genes encoding three components of 85 complex and MPB51 from BCG were analysed. The authors' analyses revealed that genes for 85A and MPB51 were transcribed as a single unit despite the one operon-like structure and these four genes were probably under a different regulatory control. These findings may help to understand the immunological and physiological roles of these antigens.

AB - The component of mycobacterial 85 Complex (85A, 85B, and 85C) and MPB51 are very important from immunological, biochemicaL, and antimycobacterial points of view. In this study, the transcriptional properties of genes encoding three components of 85 complex and MPB51 from BCG were analysed. The authors' analyses revealed that genes for 85A and MPB51 were transcribed as a single unit despite the one operon-like structure and these four genes were probably under a different regulatory control. These findings may help to understand the immunological and physiological roles of these antigens.

KW - 85 complex

KW - Mycobacterium bovis BCG

KW - mRNA analysis

KW - transcription

KW - α antigen

UR - http://www.scopus.com/inward/record.url?scp=0031278403&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031278403&partnerID=8YFLogxK

U2 - 10.1006/mpat.1997.0159

DO - 10.1006/mpat.1997.0159

M3 - Article

C2 - 9405208

AN - SCOPUS:0031278403

VL - 23

SP - 303

EP - 310

JO - Microbial Pathogenesis

JF - Microbial Pathogenesis

SN - 0882-4010

IS - 5

ER -

Characterization of the transcriptional initiation regions of genes for the major secreted protein antigens 85C and MPB51 of Mycobacterium bovis BCG

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this