Characterization of the transcriptional initiation regions of genes for the major secreted protein antigens 85C and MPB51 of Mycobacterium bovis BCG

Naoya Ohara; Takeshi Nishiyama; Naoko Ohara-Wada; Sohkichi Matsumoto; Takemitsu Matsuo; Takeshi Yamada

doi:10.1006/mpat.1997.0159

Characterization of the transcriptional initiation regions of genes for the major secreted protein antigens 85C and MPB51 of Mycobacterium bovis BCG

Naoya Ohara, Takeshi Nishiyama, Naoko Ohara-Wada, Sohkichi Matsumoto, Takemitsu Matsuo, Takeshi Yamada

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The component of mycobacterial 85 Complex (85A, 85B, and 85C) and MPB51 are very important from immunological, biochemicaL, and antimycobacterial points of view. In this study, the transcriptional properties of genes encoding three components of 85 complex and MPB51 from BCG were analysed. The authors' analyses revealed that genes for 85A and MPB51 were transcribed as a single unit despite the one operon-like structure and these four genes were probably under a different regulatory control. These findings may help to understand the immunological and physiological roles of these antigens.

Original language	English
Pages (from-to)	303-310
Number of pages	8
Journal	Microbial Pathogenesis
Volume	23
Issue number	5
DOIs	https://doi.org/10.1006/mpat.1997.0159
Publication status	Published - Nov 1997
Externally published	Yes

Keywords

85 complex
Mycobacterium bovis BCG
mRNA analysis
transcription
α antigen

ASJC Scopus subject areas

Microbiology
Infectious Diseases

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10.1006/mpat.1997.0159

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Characterization of the transcriptional initiation regions of genes for the major secreted protein antigens 85C and MPB51 of Mycobacterium bovis BCG. / Ohara, Naoya; Nishiyama, Takeshi; Ohara-Wada, Naoko; Matsumoto, Sohkichi; Matsuo, Takemitsu; Yamada, Takeshi.

In: Microbial Pathogenesis, Vol. 23, No. 5, 11.1997, p. 303-310.

Research output: Contribution to journal › Article › peer-review

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