Abstract
The component of mycobacterial 85 Complex (85A, 85B, and 85C) and MPB51 are very important from immunological, biochemicaL, and antimycobacterial points of view. In this study, the transcriptional properties of genes encoding three components of 85 complex and MPB51 from BCG were analysed. The authors' analyses revealed that genes for 85A and MPB51 were transcribed as a single unit despite the one operon-like structure and these four genes were probably under a different regulatory control. These findings may help to understand the immunological and physiological roles of these antigens.
| Original language | English |
|---|---|
| Pages (from-to) | 303-310 |
| Number of pages | 8 |
| Journal | Microbial Pathogenesis |
| Volume | 23 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Nov 1997 |
| Externally published | Yes |
Keywords
- 85 complex
- Mycobacterium bovis BCG
- mRNA analysis
- transcription
- α antigen
ASJC Scopus subject areas
- Microbiology
- Infectious Diseases
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Cite this
Ohara, N., Nishiyama, T., Ohara-Wada, N., Matsumoto, S., Matsuo, T., & Yamada, T. (1997). Characterization of the transcriptional initiation regions of genes for the major secreted protein antigens 85C and MPB51 of Mycobacterium bovis BCG. Microbial Pathogenesis, 23(5), 303-310. https://doi.org/10.1006/mpat.1997.0159