Abstract
The component of mycobacterial 85 Complex (85A, 85B, and 85C) and MPB51 are very important from immunological, biochemicaL, and antimycobacterial points of view. In this study, the transcriptional properties of genes encoding three components of 85 complex and MPB51 from BCG were analysed. The authors' analyses revealed that genes for 85A and MPB51 were transcribed as a single unit despite the one operon-like structure and these four genes were probably under a different regulatory control. These findings may help to understand the immunological and physiological roles of these antigens.
| Original language | English |
|---|---|
| Pages (from-to) | 303-310 |
| Number of pages | 8 |
| Journal | Microbial Pathogenesis |
| Volume | 23 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Nov 1997 |
| Externally published | Yes |
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Keywords
- α antigen
- 85 complex
- mRNA analysis
- Mycobacterium bovis BCG
- transcription
ASJC Scopus subject areas
- Microbiology
- Infectious Diseases
Cite this
Characterization of the transcriptional initiation regions of genes for the major secreted protein antigens 85C and MPB51 of Mycobacterium bovis BCG. / Oohara, Naoya; Nishiyama, Takeshi; Ohara-Wada, Naoko; Matsumoto, Sohkichi; Matsuo, Takemitsu; Yamada, Takeshi.
In: Microbial Pathogenesis, Vol. 23, No. 5, 11.1997, p. 303-310.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characterization of the transcriptional initiation regions of genes for the major secreted protein antigens 85C and MPB51 of Mycobacterium bovis BCG
AU - Oohara, Naoya
AU - Nishiyama, Takeshi
AU - Ohara-Wada, Naoko
AU - Matsumoto, Sohkichi
AU - Matsuo, Takemitsu
AU - Yamada, Takeshi
PY - 1997/11
Y1 - 1997/11
N2 - The component of mycobacterial 85 Complex (85A, 85B, and 85C) and MPB51 are very important from immunological, biochemicaL, and antimycobacterial points of view. In this study, the transcriptional properties of genes encoding three components of 85 complex and MPB51 from BCG were analysed. The authors' analyses revealed that genes for 85A and MPB51 were transcribed as a single unit despite the one operon-like structure and these four genes were probably under a different regulatory control. These findings may help to understand the immunological and physiological roles of these antigens.
AB - The component of mycobacterial 85 Complex (85A, 85B, and 85C) and MPB51 are very important from immunological, biochemicaL, and antimycobacterial points of view. In this study, the transcriptional properties of genes encoding three components of 85 complex and MPB51 from BCG were analysed. The authors' analyses revealed that genes for 85A and MPB51 were transcribed as a single unit despite the one operon-like structure and these four genes were probably under a different regulatory control. These findings may help to understand the immunological and physiological roles of these antigens.
KW - α antigen
KW - 85 complex
KW - mRNA analysis
KW - Mycobacterium bovis BCG
KW - transcription
UR - http://www.scopus.com/inward/record.url?scp=0031278403&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031278403&partnerID=8YFLogxK
U2 - 10.1006/mpat.1997.0159
DO - 10.1006/mpat.1997.0159
M3 - Article
C2 - 9405208
AN - SCOPUS:0031278403
VL - 23
SP - 303
EP - 310
JO - Microbial Pathogenesis
JF - Microbial Pathogenesis
SN - 0882-4010
IS - 5
ER -