Characterization of the transcriptional initiation regions of genes for the major secreted protein antigens 85C and MPB51 of Mycobacterium bovis BCG

Naoya Oohara, Takeshi Nishiyama, Naoko Ohara-Wada, Sohkichi Matsumoto, Takemitsu Matsuo, Takeshi Yamada

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13 Citations (Scopus)

Abstract

The component of mycobacterial 85 Complex (85A, 85B, and 85C) and MPB51 are very important from immunological, biochemicaL, and antimycobacterial points of view. In this study, the transcriptional properties of genes encoding three components of 85 complex and MPB51 from BCG were analysed. The authors' analyses revealed that genes for 85A and MPB51 were transcribed as a single unit despite the one operon-like structure and these four genes were probably under a different regulatory control. These findings may help to understand the immunological and physiological roles of these antigens.

Original languageEnglish
Pages (from-to)303-310
Number of pages8
JournalMicrobial Pathogenesis
Volume23
Issue number5
DOIs
Publication statusPublished - Nov 1997
Externally publishedYes

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Keywords

  • α antigen
  • 85 complex
  • mRNA analysis
  • Mycobacterium bovis BCG
  • transcription

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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