Abstract
Itching is known as a commonly side effect of opioid administration. However, the relationship of opioid receptors to itching is unclear. In this study, we examined the effect of intradermal injection of morphine and fentanyl on the itching sensation. When injected intradermally into the rostral back of mice, morphine and fentanyl elicited scratching behavior. In addition, an opioid receptor antagonist, naloxone, and a peripherally restricted opioid receptor antagonist, naloxone methiodide, significantly suppressed morphine- and fentanyl-induced scratching behavior. Moreover, the morphine-induced scratching behavior was suppressed by histamine H1 receptor antagonists, such as diphenhydramine, chlorpheniramine, epinastine and cetirizine. On the other hand, fentanyl-induced scratching behavior was not suppressed by histamine H1 receptor antagonists. Additionally, scratching behavior induced by morphine and fentanyl were not suppressed by glucocorticoids (predonisolone and dexamethasone). In conclusion, opioid-induced itching may involve in peripheral opioid receptors. Moreover, histamine and arachidonic acid metabolites played no main role in opioid-induced scratching behavior.
| Original language | English |
|---|---|
| Pages (from-to) | 162-166 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 627 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - Feb 10 2010 |
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Keywords
- Fentanyl
- Itch
- Morphine
- Naloxone methiodide
- Peripheral opioid receptor
- Scratching behavior
ASJC Scopus subject areas
- Pharmacology
Cite this
Characterization of scratching behavior induced by intradermal administration of morphine and fentanyl in mice. / Yamamoto, Atsuki; Kuyama, Shoji; Kamei, Chiaki; Sugimoto, Yukio.
In: European Journal of Pharmacology, Vol. 627, No. 1-3, 10.02.2010, p. 162-166.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characterization of scratching behavior induced by intradermal administration of morphine and fentanyl in mice
AU - Yamamoto, Atsuki
AU - Kuyama, Shoji
AU - Kamei, Chiaki
AU - Sugimoto, Yukio
PY - 2010/2/10
Y1 - 2010/2/10
N2 - Itching is known as a commonly side effect of opioid administration. However, the relationship of opioid receptors to itching is unclear. In this study, we examined the effect of intradermal injection of morphine and fentanyl on the itching sensation. When injected intradermally into the rostral back of mice, morphine and fentanyl elicited scratching behavior. In addition, an opioid receptor antagonist, naloxone, and a peripherally restricted opioid receptor antagonist, naloxone methiodide, significantly suppressed morphine- and fentanyl-induced scratching behavior. Moreover, the morphine-induced scratching behavior was suppressed by histamine H1 receptor antagonists, such as diphenhydramine, chlorpheniramine, epinastine and cetirizine. On the other hand, fentanyl-induced scratching behavior was not suppressed by histamine H1 receptor antagonists. Additionally, scratching behavior induced by morphine and fentanyl were not suppressed by glucocorticoids (predonisolone and dexamethasone). In conclusion, opioid-induced itching may involve in peripheral opioid receptors. Moreover, histamine and arachidonic acid metabolites played no main role in opioid-induced scratching behavior.
AB - Itching is known as a commonly side effect of opioid administration. However, the relationship of opioid receptors to itching is unclear. In this study, we examined the effect of intradermal injection of morphine and fentanyl on the itching sensation. When injected intradermally into the rostral back of mice, morphine and fentanyl elicited scratching behavior. In addition, an opioid receptor antagonist, naloxone, and a peripherally restricted opioid receptor antagonist, naloxone methiodide, significantly suppressed morphine- and fentanyl-induced scratching behavior. Moreover, the morphine-induced scratching behavior was suppressed by histamine H1 receptor antagonists, such as diphenhydramine, chlorpheniramine, epinastine and cetirizine. On the other hand, fentanyl-induced scratching behavior was not suppressed by histamine H1 receptor antagonists. Additionally, scratching behavior induced by morphine and fentanyl were not suppressed by glucocorticoids (predonisolone and dexamethasone). In conclusion, opioid-induced itching may involve in peripheral opioid receptors. Moreover, histamine and arachidonic acid metabolites played no main role in opioid-induced scratching behavior.
KW - Fentanyl
KW - Itch
KW - Morphine
KW - Naloxone methiodide
KW - Peripheral opioid receptor
KW - Scratching behavior
UR - http://www.scopus.com/inward/record.url?scp=73449090756&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73449090756&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2009.10.066
DO - 10.1016/j.ejphar.2009.10.066
M3 - Article
C2 - 19900440
AN - SCOPUS:73449090756
VL - 627
SP - 162
EP - 166
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1-3
ER -