Characterization of inhibitory effects of perfluorooctane sulfonate on human hepatic cytochrome P450 isoenzymes: Focusing on CYP2A6

Medicine & Life Sciences

• perfluorooctane sulfonic acid 100%
• Isoenzymes 64%
• Cytochrome P-450 Enzyme System 62%
• Liver 33%
• Hydroxylation 29%
• Cytochrome P-450 CYP2C9 25%
• Cytochrome P-450 CYP2C8 19%
• Cytochrome P-450 CYP2B6 18%
• Cytochrome P-450 CYP2C19 16%
• Cytochrome P-450 CYP2E1 16%
• Cytochrome P-450 CYP1A2 16%
• Cytochrome P-450 CYP2D6 16%
• Diclofenac 15%
• Cytochrome P-450 CYP3A 14%
• 7-ethoxy-4-trifluoromethylcoumarin 13%
• Paclitaxel 13%
• coumarin 7 11%
• bufuralol 11%
• Chlorzoxazone 10%
• Mephenytoin 10%
• ethoxyresorufin 9%
• coumarin 8%
• NADP 6%
• Surface-Active Agents 6%
• Oils 6%
• Human Body 6%
• Mammals 5%
• Testosterone 5%
• Kinetics 4%
• Water 4%
• Enzymes 3%
• Pharmaceutical Preparations 2%

Chemical Compounds

• Perfluorooctane 95%
• Cytochrome P450 68%
• Sulfonate 59%
• Diclofenac 15%
• Coumarin 13%
• Bufuralol 11%
• Repellent 8%
• Testosterone 7%
• Surface-Active Agent 7%
• Pharmacological Metabolism 4%
• Drug 3%
• Time 2%