Abstract
Transformed Fisher rat fibroblast cell lines by Abelson murine leukemia virus frequently revert to the normal phenotype in usual culture conditions. Molecular biological analysis of three revertant clones isolated from the transformants showed that their morphological reversions were due to inactivation of the v-abl oncogene at multiple steps including transcription, translation or v-abl protein kinase activity itself without any change in structural gene expression of helper virus. These findings suggest the existence of a specific mechanism(s) for elimination of the v-abl oncogene by segregation, mutation, or gene rearrangement in these cells.
| Original language | English |
|---|---|
| Pages (from-to) | 428-433 |
| Number of pages | 6 |
| Journal | Journal of Cellular Physiology |
| Volume | 145 |
| Issue number | 3 |
| Publication status | Published - Dec 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Clinical Biochemistry
- Cell Biology
- Physiology
Cite this
Characterization of flat revertants isolated from cells transformed by Abelson murine leukemia virus (Ab-MuLV). / Oka, Takashi; Yutsudo, Masuo; Inoue, Hirokazu; Higuchi, Fujito; Hakura, Akira.
In: Journal of Cellular Physiology, Vol. 145, No. 3, 12.1990, p. 428-433.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characterization of flat revertants isolated from cells transformed by Abelson murine leukemia virus (Ab-MuLV)
AU - Oka, Takashi
AU - Yutsudo, Masuo
AU - Inoue, Hirokazu
AU - Higuchi, Fujito
AU - Hakura, Akira
PY - 1990/12
Y1 - 1990/12
N2 - Transformed Fisher rat fibroblast cell lines by Abelson murine leukemia virus frequently revert to the normal phenotype in usual culture conditions. Molecular biological analysis of three revertant clones isolated from the transformants showed that their morphological reversions were due to inactivation of the v-abl oncogene at multiple steps including transcription, translation or v-abl protein kinase activity itself without any change in structural gene expression of helper virus. These findings suggest the existence of a specific mechanism(s) for elimination of the v-abl oncogene by segregation, mutation, or gene rearrangement in these cells.
AB - Transformed Fisher rat fibroblast cell lines by Abelson murine leukemia virus frequently revert to the normal phenotype in usual culture conditions. Molecular biological analysis of three revertant clones isolated from the transformants showed that their morphological reversions were due to inactivation of the v-abl oncogene at multiple steps including transcription, translation or v-abl protein kinase activity itself without any change in structural gene expression of helper virus. These findings suggest the existence of a specific mechanism(s) for elimination of the v-abl oncogene by segregation, mutation, or gene rearrangement in these cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025648427&partnerID=8YFLogxK
M3 - Article
VL - 145
SP - 428
EP - 433
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
SN - 0021-9541
IS - 3
ER -