Characterization of flat revertants isolated from cells transformed by Abelson murine leukemia virus (Ab‐MuLV)

Takashi Oka, Masuo Yutsudo, Hirokazu Inoue, Fujito Higuchi, Akira Hakura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Transformed Fisher rat fibroblast cell lines by Abelson murine leukemia virus frequently revert to the normal phenotype in usual culture conditions. Molecular Biological analysis of thre revertant clones isolated from the transformants showed that their morphological reversions were due to inactivation of the v‐abl oncogene at multiple steps including transcription, translation or v‐abl protein kinase activity itself without any change in structural gene expression of helper virus. These findings suggest the existence of a specific mechanism(s) for elimination of the v‐abl oncogene by segregation, mutation, or gene rearrangement in these cells.

Original languageEnglish
Pages (from-to)428-433
Number of pages6
JournalJournal of cellular physiology
Volume145
Issue number3
DOIs
Publication statusPublished - Dec 1990
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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