TY - JOUR
T1 - Characterization of flat revertants isolated from cells transformed by Abelson murine leukemia virus (Ab‐MuLV)
AU - Oka, Takashi
AU - Yutsudo, Masuo
AU - Inoue, Hirokazu
AU - Higuchi, Fujito
AU - Hakura, Akira
PY - 1990/12
Y1 - 1990/12
N2 - Transformed Fisher rat fibroblast cell lines by Abelson murine leukemia virus frequently revert to the normal phenotype in usual culture conditions. Molecular Biological analysis of thre revertant clones isolated from the transformants showed that their morphological reversions were due to inactivation of the v‐abl oncogene at multiple steps including transcription, translation or v‐abl protein kinase activity itself without any change in structural gene expression of helper virus. These findings suggest the existence of a specific mechanism(s) for elimination of the v‐abl oncogene by segregation, mutation, or gene rearrangement in these cells.
AB - Transformed Fisher rat fibroblast cell lines by Abelson murine leukemia virus frequently revert to the normal phenotype in usual culture conditions. Molecular Biological analysis of thre revertant clones isolated from the transformants showed that their morphological reversions were due to inactivation of the v‐abl oncogene at multiple steps including transcription, translation or v‐abl protein kinase activity itself without any change in structural gene expression of helper virus. These findings suggest the existence of a specific mechanism(s) for elimination of the v‐abl oncogene by segregation, mutation, or gene rearrangement in these cells.
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U2 - 10.1002/jcp.1041450306
DO - 10.1002/jcp.1041450306
M3 - Article
C2 - 1703165
AN - SCOPUS:0025648427
VL - 145
SP - 428
EP - 433
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
SN - 0021-9541
IS - 3
ER -