Characterization of blaNDM-5-harbouring Klebsiella pneumoniae sequence type 11 international high-risk clones isolated from clinical samples in Yangon General Hospital, a tertiary-care hospital in Myanmar

Yo Sugawara; Yukihiro Akeda; Hideharu Hagiya; Khwar Nyo Zin; Mya Mya Aye; Dan Takeuchi; Yuki Matsumoto; Daisuke Motooka; Isao Nishi; Kazunori Tomono; Shigeyuki Hamada

doi:10.1099/JMM.0.001348

Characterization of bla_NDM-5-harbouring Klebsiella pneumoniae sequence type 11 international high-risk clones isolated from clinical samples in Yangon General Hospital, a tertiary-care hospital in Myanmar

Yo Sugawara, Yukihiro Akeda, Hideharu Hagiya, Khwar Nyo Zin, Mya Mya Aye, Dan Takeuchi, Yuki Matsumoto, Daisuke Motooka, Isao Nishi, Kazunori Tomono, Shigeyuki Hamada

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Fifteen Klebsiella pneumoniae isolates harbouring bla_NDM genes were identified from blood and sputum specimens of patients at a tertiary-care facility (Yangon General Hospital, Yangon, Myanmar) in 2018. Two of the isolates belonged to sequence type (ST) 11, an international high-risk clone. Whole-genome sequencing and phylogenetic analyses revealed that these two isolates were clustered together with other ST11 isolates originating from other countries. The isolates harboured the bla_NDM-5 gene on an IncFII-type plasmid that is prevalent among carbapenemase-producing Enterobacteriaceae in Yangon but has rarely been found in other ST11 isolates. Our data suggests the regional presence of the ST11 international high-risk clone and its acquisition of an endemic bla_NDM-5-carrying plasmid.

Original language	English
Article number	001348
Journal	Journal of Medical Microbiology
Volume	70
Issue number	5
DOIs	https://doi.org/10.1099/JMM.0.001348
Publication status	Published - 2021
Externally published	Yes

Keywords

Bla
Carbapenem-resistant enterobacteriaceae
IncFII
Klebsiella pneumoniae
Myanmar

ASJC Scopus subject areas

Microbiology
Microbiology (medical)

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10.1099/JMM.0.001348

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Sugawara, Y., Akeda, Y., Hagiya, H., Zin, K. N., Aye, M. M., Takeuchi, D., Matsumoto, Y., Motooka, D., Nishi, I., Tomono, K., & Hamada, S. (2021). Characterization of bla_NDM-5-harbouring Klebsiella pneumoniae sequence type 11 international high-risk clones isolated from clinical samples in Yangon General Hospital, a tertiary-care hospital in Myanmar. Journal of Medical Microbiology, 70(5), [001348]. https://doi.org/10.1099/JMM.0.001348

Characterization of bla_NDM-5-harbouring Klebsiella pneumoniae sequence type 11 international high-risk clones isolated from clinical samples in Yangon General Hospital, a tertiary-care hospital in Myanmar. / Sugawara, Yo; Akeda, Yukihiro; Hagiya, Hideharu et al.

In: Journal of Medical Microbiology, Vol. 70, No. 5, 001348, 2021.

Research output: Contribution to journal › Article › peer-review

Sugawara, Y, Akeda, Y, Hagiya, H, Zin, KN, Aye, MM, Takeuchi, D, Matsumoto, Y, Motooka, D, Nishi, I, Tomono, K & Hamada, S 2021, 'Characterization of bla_NDM-5-harbouring Klebsiella pneumoniae sequence type 11 international high-risk clones isolated from clinical samples in Yangon General Hospital, a tertiary-care hospital in Myanmar', Journal of Medical Microbiology, vol. 70, no. 5, 001348. https://doi.org/10.1099/JMM.0.001348

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abstract = "Fifteen Klebsiella pneumoniae isolates harbouring blaNDM genes were identified from blood and sputum specimens of patients at a tertiary-care facility (Yangon General Hospital, Yangon, Myanmar) in 2018. Two of the isolates belonged to sequence type (ST) 11, an international high-risk clone. Whole-genome sequencing and phylogenetic analyses revealed that these two isolates were clustered together with other ST11 isolates originating from other countries. The isolates harboured the blaNDM-5 gene on an IncFII-type plasmid that is prevalent among carbapenemase-producing Enterobacteriaceae in Yangon but has rarely been found in other ST11 isolates. Our data suggests the regional presence of the ST11 international high-risk clone and its acquisition of an endemic blaNDM-5-carrying plasmid.",

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AU - Hamada, Shigeyuki

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