Characterization of Arabidopsis decapping proteins AtDCP1 and AtDCP2, which are essential for post-embryonic development

Shintaro Iwasaki, Atsushi Takeda, Hiroyasu Motose, Yuichiro Watanabe

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Although decapping is an important process in eukaryotic mRNA turnover, little is known about this process in plants. Here, we identified Arabidopsis thaliana decapping proteins AtDCP1 and AtDCP2 and showed that (I) AtDCP2 is an active decapping enzyme, (II) AtDCP1 interacts with itself, (III) AtDCP1 and AtDCP2 are localized to cytoplasmic foci (putative Arabidopsis processing body), and (IV) AtDCP1 and AtDCP2 are essential for post-embryonic development. Our findings provide new insights into the role of decapping-dependent mRNA turnover.

Original languageEnglish
Pages (from-to)2455-2459
Number of pages5
JournalFEBS Letters
Volume581
Issue number13
DOIs
Publication statusPublished - May 29 2007
Externally publishedYes

Keywords

  • Arabidopsis thaliana
  • DCP1
  • DCP2
  • Decapping
  • Processing body
  • mRNA turnover

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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