Characterization of aortic aneurysms in cardiovascular disease patients harboring Porphyromonas gingivalis

K. Nakano, K. Wada, R. Nomura, H. Nemoto, H. Inaba, A. Kojima, S. Naka, K. Hokamura, T. Mukai, A. Nakajima, K. Umemura, Y. Kamisaki, H. Yoshioka, K. Taniguchi, A. Amano, T. Ooshima

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: Porphyromonas gingivalis was recently shown to cause intimal hyperplasia in a mouse model by a novel cholesterol-independent mechanism, suggesting to be a pathogen-specific feature of cardiovascular diseases. The aim of this study was to characterize the clinical and histopathological features of aortic aneurysms in cardiovascular disease patients harboring oral P. gingivalis. Subject and methods: Aortic aneurysm specimens were collected from 76 Japanese patients who underwent surgery, of whom dental plaque specimens were also collected from 31 patients. Bacterial DNA was extracted from each specimen to detect P. gingivalis by polymerase chain reaction. Histopathological analyses of the aortic aneurysm specimens, including immunohistochemical staining for embryonic myosin heavy chain isoform (SMemb) and S100 calcium-binding protein A9 (S100A9), were also performed. Results: The number of aneurysms occurring in the distal aorta was significantly higher in subjects positive for P. gingivalis in dental plaque compared with those who were negative. The expressions of S100A9 and SMemb were also significantly greater in the subjects positive for P. gingivalis in dental plaque. On the other hand, there were no significant differences in adipocellular accumulation between the groups. Conclusions: These results suggest that aortic aneurysms in patients harboring oral P. gingivalis have greater expression of S100A9 and proliferative smooth muscle cells, which was different from the present patients without oral P. gingivalis.

Original languageEnglish
Pages (from-to)370-378
Number of pages9
JournalOral Diseases
Volume17
Issue number4
DOIs
Publication statusPublished - May 2011

Keywords

  • Aortic aneurysm
  • Embryonic myosin heavy chain isoform
  • Intimal hyperplasia
  • Porphyromonas gingivalis
  • S100 calcium-binding protein a9
  • Smooth muscle cells

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)

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    Nakano, K., Wada, K., Nomura, R., Nemoto, H., Inaba, H., Kojima, A., Naka, S., Hokamura, K., Mukai, T., Nakajima, A., Umemura, K., Kamisaki, Y., Yoshioka, H., Taniguchi, K., Amano, A., & Ooshima, T. (2011). Characterization of aortic aneurysms in cardiovascular disease patients harboring Porphyromonas gingivalis. Oral Diseases, 17(4), 370-378. https://doi.org/10.1111/j.1601-0825.2010.01759.x