Characterization and protein adsorption ability of zinc, iron and magnesium hydroxyapatite

T. Tonegawa, T. Ikoma, T. Yoshioka, G. Chen, N. Hanagata, J. Tanaka

Research output: Contribution to journalArticle

6 Citations (Scopus)


The adsorption properties of metal ions containing hydroxyapatite (Ca 10(PO4)6(OH)2, HAp) were elucidated for the development of protein drug carrier. As-prepared metal ion containing HAp nanocrystal showed plate-like morphology with 10-20nm in length and 5-10nm in width. The metal ion containing HAp microparticles had higher specific surface area than the HAp microparticle. The adsorption amount per unit area of HAp showed higher than those of metal ion containing HAp. The adsorption behavior followed the Langmuir curves for each protein, indicating the monolayer adsorption. The loaded amount of proteins could be one of the most important properties for the application of drug delivery carrier.

Original languageEnglish
Pages (from-to)187-190
Number of pages4
JournalKey Engineering Materials
Volume361-363 I
Publication statusPublished - Jan 22 2008
Externally publishedYes



  • Drug delivery system
  • Hydroxyapatite
  • Iron
  • Magnesium
  • Nanocrystal
  • Proteins adsorption
  • Spray drying method
  • Zinc

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Tonegawa, T., Ikoma, T., Yoshioka, T., Chen, G., Hanagata, N., & Tanaka, J. (2008). Characterization and protein adsorption ability of zinc, iron and magnesium hydroxyapatite. Key Engineering Materials, 361-363 I, 187-190.