Characterization and horizontal transfer of class 1 integrons in Salmonella strains isolated from food products of animal origin

Hecheng Meng, Zhigang Zhang, Miaorui Chen, Yongyu Su, Lin Li, Shin ichi Miyoshi, He Yan, Lei Shi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A total of 81 Salmonella isolates from retail meats and seafood in Hebei province, China, were assayed for the presence of and horizontal transfer of class 1 integrons. By the PCR screening for the integrons, class 1 integron was detected from strains in serotypes of Derby, Indiana, London and Choleraesuis, which were isolated from pork, chicken or seafood; however, two isolates contained the empty integron that lacked the resistance cassette, a potential hotspot for development of the multidrug resistance. In contrast, two other isolates had the antibiotic resistance gene cassettes within the class 1 integron, which were dfrA1-aadA1 and aadB-cmlA, respectively. The conjugation experiments demonstrated the plasmid-mediated transfer of the class 1 integrons. Furthermore, each of the integrons was transmitted to Streptococcus mutans via natural gene transformation. These findings suggest the possible transfer of class 1 integrons from foodborne pathogens to human residential bacteria via horizontal gene transfer.

Original languageEnglish
Pages (from-to)274-277
Number of pages4
JournalInternational Journal of Food Microbiology
Volume149
Issue number3
DOIs
Publication statusPublished - Oct 3 2011

Keywords

  • Antimicrobial resistance
  • Class 1 integron
  • Gene transfer
  • Salmonella

ASJC Scopus subject areas

  • Food Science
  • Microbiology

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