Characteristics of slow waves on EEG associated with epileptic spasms

Katsuhiro Kobayashi, Makio Oka, Takushi Inoue, Tatsuya Ogino, Harumi Yoshinaga, Yoko Ohtsuka

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Purpose: The high-voltage slow waves (HVSs) on EEG associated with epileptic spasms were investigated to clarify their characteristics and their relation to the pathophysiology of spasms in West syndrome and related disorders. Methods: In 14 patients, digitally recorded EEG segments showing the ictal HVSs were extracted and their traces were overlaid by using an average reference. The ictal HVSs were also averaged to build maps for investigation of the pattern of potential distribution over the scalp. Results: In a total of 685 recorded spasms, 346 (50.5%) with minimal artifacts were selected to demonstrate that the ictal HVSs had a largely consistent waveform and distribution in each patient. The ictal HVSs were symmetrical in 1.0 patients and asymmetrical in the other four, and were relatively negative over the posterior region and positive over the frontal or temporal regions in 11 patients. Two symptomatic patients showed a marked deviation of the distribution of HVSs to the pathologically more involved hemisphere. An infant with Aicardi syndrome had two different types of spasms, each type showing a consistent pattern of HVSs with a lateralized distribution. Conclusions: The patterns of distribution of the ictal HVS may be related to the abnormal activation of the brain in the generation of spasms.

Original languageEnglish
Pages (from-to)1098-1105
Number of pages8
JournalEpilepsia
Volume46
Issue number7
DOIs
Publication statusPublished - Jul 2005

Fingerprint

Spasm
Electroencephalography
Stroke
Aicardi Syndrome
Infantile Spasms
Temporal Lobe
Scalp
Artifacts
Brain

Keywords

  • EEG
  • Map
  • Slow wave
  • Spasm
  • West syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Characteristics of slow waves on EEG associated with epileptic spasms. / Kobayashi, Katsuhiro; Oka, Makio; Inoue, Takushi; Ogino, Tatsuya; Yoshinaga, Harumi; Ohtsuka, Yoko.

In: Epilepsia, Vol. 46, No. 7, 07.2005, p. 1098-1105.

Research output: Contribution to journalArticle

Kobayashi, Katsuhiro ; Oka, Makio ; Inoue, Takushi ; Ogino, Tatsuya ; Yoshinaga, Harumi ; Ohtsuka, Yoko. / Characteristics of slow waves on EEG associated with epileptic spasms. In: Epilepsia. 2005 ; Vol. 46, No. 7. pp. 1098-1105.
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