Characteristics of serious complicated gastroduodenal ulcers in Japan

Shigenao Ishikawa, Tomoki Inaba, Motowo Mizuno, Yasuhiro Miyake, Hiroyuki Okada, Hisashi Ishikawa, Keisuke Hori, Masaki Wato, Kozo Kawai, Kazuhide Yamamoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background/Aims: Even in Japan where the incidence of H. pylori infection is high, patients with gastroduodenal ulcers caused by NSAIDs are on the increase. A prospective study was conducted to elucidate the characteristics of gastroduodenal ulcers complicated with ulcerous hemorrhage and perforation among Japanese. Methodology: The subjects were 305 consecutive cases with hemorrhaging ulcers and 76 consecutive cases with perforated ulcers basis at Kagawa Prefectural Central Hospital between January 2000 and December 2008. These subjects were divided into 3 groups (low-dose aspirin, non-aspirin NSAIDs and non-NSAIDs) and were further stratified by the presence of an H. pylori infection. Results: The 76 perforating ulcers were composed of 54 non-NSAIDs ulcers and 22 NSAIDs-related ulcers. The 305 hemorrhaging ulcers were composed of 156 non-NSAIDs ulcers, 94 non-aspirin NSAIDs ulcers and 55 on low-dose aspirin. The mortality for the non-aspirin NSAIDs group (12.8%, 12/94) and for the low-dose aspirin group (10.9%, 6/55) was significantly higher (p

Original languageEnglish
Pages (from-to)147-154
Number of pages8
JournalHepato-Gastroenterology
Volume59
Issue number113
DOIs
Publication statusPublished - Jan 2012

Fingerprint

Peptic Ulcer
Ulcer
Japan
Non-Steroidal Anti-Inflammatory Agents
Aspirin
Pylorus
Infection
Prospective Studies
Hemorrhage
Mortality
Incidence

Keywords

  • Bleeding ulcer
  • Complication
  • Gastroduodenal ulcer
  • Low-dose aspirin
  • Non-steroidal anti-inflammatory drugs (NSAID)
  • Perforated ulcer

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Ishikawa, S., Inaba, T., Mizuno, M., Miyake, Y., Okada, H., Ishikawa, H., ... Yamamoto, K. (2012). Characteristics of serious complicated gastroduodenal ulcers in Japan. Hepato-Gastroenterology, 59(113), 147-154. https://doi.org/10.5754/hge09689

Characteristics of serious complicated gastroduodenal ulcers in Japan. / Ishikawa, Shigenao; Inaba, Tomoki; Mizuno, Motowo; Miyake, Yasuhiro; Okada, Hiroyuki; Ishikawa, Hisashi; Hori, Keisuke; Wato, Masaki; Kawai, Kozo; Yamamoto, Kazuhide.

In: Hepato-Gastroenterology, Vol. 59, No. 113, 01.2012, p. 147-154.

Research output: Contribution to journalArticle

Ishikawa, S, Inaba, T, Mizuno, M, Miyake, Y, Okada, H, Ishikawa, H, Hori, K, Wato, M, Kawai, K & Yamamoto, K 2012, 'Characteristics of serious complicated gastroduodenal ulcers in Japan', Hepato-Gastroenterology, vol. 59, no. 113, pp. 147-154. https://doi.org/10.5754/hge09689
Ishikawa S, Inaba T, Mizuno M, Miyake Y, Okada H, Ishikawa H et al. Characteristics of serious complicated gastroduodenal ulcers in Japan. Hepato-Gastroenterology. 2012 Jan;59(113):147-154. https://doi.org/10.5754/hge09689
Ishikawa, Shigenao ; Inaba, Tomoki ; Mizuno, Motowo ; Miyake, Yasuhiro ; Okada, Hiroyuki ; Ishikawa, Hisashi ; Hori, Keisuke ; Wato, Masaki ; Kawai, Kozo ; Yamamoto, Kazuhide. / Characteristics of serious complicated gastroduodenal ulcers in Japan. In: Hepato-Gastroenterology. 2012 ; Vol. 59, No. 113. pp. 147-154.
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