Characteristics of bone morphogenetic protein-induced chondroid bone: Histochemical, immunohistochemical and in situ hybridization examinations

T. Kawakami, T. Kawai, A. Kimura, H. Hasegawa, H. Tsujigiwa, M. Gunduz, H. Nagatsuka, N. Nagai

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The third ossification mode, known as transchondroid bone formation, is displayed chiefly in the bone morphogenetic protein (BMP)-induced heterotopic bone formation model. This paper describes the results of histopathological, histochemical, immunohistochemical, and in situ hybridization examinations of BMP-induced heterotopic bone in mice. The research focuses on the localization of typical matrix proteins (peptide and its mRNA) of cartilage and bone - type-I and type-II collagen, osteocalcin and osteopontin - in the chondroid bone matrix.

Original languageEnglish
Pages (from-to)480-487
Number of pages8
JournalJournal of International Medical Research
Volume29
Issue number6
DOIs
Publication statusPublished - 2001

Keywords

  • Bone matrix
  • Bone morphogenetic protein
  • Chondroid bone
  • Immunohistochemistry
  • In situ hybridization
  • MRNA
  • Ossification

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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