Characteristics of bone morphogenetic protein-induced chondroid bone: Histochemical, immunohistochemical and in situ hybridization examinations

T. Kawakami, T. Kawai, A. Kimura, H. Hasegawa, H. Tsujigiwa, M. Gunduz, Hitoshi Nagatsuka, N. Nagai

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The third ossification mode, known as transchondroid bone formation, is displayed chiefly in the bone morphogenetic protein (BMP)-induced heterotopic bone formation model. This paper describes the results of histopathological, histochemical, immunohistochemical, and in situ hybridization examinations of BMP-induced heterotopic bone in mice. The research focuses on the localization of typical matrix proteins (peptide and its mRNA) of cartilage and bone - type-I and type-II collagen, osteocalcin and osteopontin - in the chondroid bone matrix.

Original languageEnglish
Pages (from-to)480-487
Number of pages8
JournalJournal of International Medical Research
Volume29
Issue number6
Publication statusPublished - 2001

Fingerprint

Bone Morphogenetic Proteins
Osteogenesis
In Situ Hybridization
Bone
Bone and Bones
Bone Matrix
Osteopontin
Collagen Type II
Osteocalcin
Collagen Type I
Cartilage
Messenger RNA
Peptides
Research
Proteins

Keywords

  • Bone matrix
  • Bone morphogenetic protein
  • Chondroid bone
  • Immunohistochemistry
  • In situ hybridization
  • MRNA
  • Ossification

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Characteristics of bone morphogenetic protein-induced chondroid bone : Histochemical, immunohistochemical and in situ hybridization examinations. / Kawakami, T.; Kawai, T.; Kimura, A.; Hasegawa, H.; Tsujigiwa, H.; Gunduz, M.; Nagatsuka, Hitoshi; Nagai, N.

In: Journal of International Medical Research, Vol. 29, No. 6, 2001, p. 480-487.

Research output: Contribution to journalArticle

Kawakami, T. ; Kawai, T. ; Kimura, A. ; Hasegawa, H. ; Tsujigiwa, H. ; Gunduz, M. ; Nagatsuka, Hitoshi ; Nagai, N. / Characteristics of bone morphogenetic protein-induced chondroid bone : Histochemical, immunohistochemical and in situ hybridization examinations. In: Journal of International Medical Research. 2001 ; Vol. 29, No. 6. pp. 480-487.
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AU - Tsujigiwa, H.

AU - Gunduz, M.

AU - Nagatsuka, Hitoshi

AU - Nagai, N.

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KW - Immunohistochemistry

KW - In situ hybridization

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