Characteristic Distribution Pattern of CD30-positive Cytotoxic T Cells Aids Diagnosis of Kikuchi-Fujimoto Disease

Tetsuya Tabata, Katsuyoshi Takata, Tomoko Miyata-Takata, Yasuharu Sato, Shin Ishizawa, Tomoyoshi Kunitomo, Keina Nagakita, Nobuhiko Ohnishi, Kouhei Taniguchi, Mai Noujima-Harada, Yoshinobu Maeda, Mitsune Tanimoto, Tadashi Yoshino

Research output: Contribution to journalArticle

Abstract

INTRODUCTION:: Histiocytic necrotizing lymphadenitis (or Kikuchi-Fujimoto disease) frequently occurs in Asian young adult females and typically presents as cervical lymphadenopathy with unknown etiology. Although large immunoblasts frequently appear in Kikuchi-Fujimoto disease, the diffuse infiltration of these cells can cause difficulty in establishing a differential diagnosis from lymphoma. In such cases, CD30 immunostaining may be used; however, the extent or distribution pattern of CD30-positive cells in Kikuchi-Fujimoto disease remains largely unknown. Here we investigated the expression of CD30 and its clinicopathologic significance. MATERIALS AND METHODS:: We investigated 30 Kikuchi-Fujimoto disease and 16 control [6, systemic lupus erythematosus (SLE); 10, reactive lymphoid hyperplasia (RLH)] cases. RESULTS:: The number of CD30-positive cells in Kikuchi-Fujimoto disease was significantly more than that in SLE and RLH, and majority of these cells were located around necrotic areas. Moreover, double immunohistochemical staining showed these CD30-positive cells to be CD8-positive cytotoxic T cells, suggesting that activated cytotoxic T cells around necrotic areas are a characteristic feature of this disease. Clinicopathologic analysis showed that cases with abundant CD30-positive cells were predominantly female with only mild symptoms and normal laboratory data. CONCLUSIONS:: In Kikuchi-Fujimoto disease cases, CD30-positive cytotoxic T cells were abundant around necrotic areas; this histologic feature may be helpful to differentiate this disease from SLE and RLH.

Original languageEnglish
JournalApplied Immunohistochemistry and Molecular Morphology
DOIs
Publication statusAccepted/In press - Jul 6 2016

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Histiocytic Necrotizing Lymphadenitis
T-Lymphocytes
Pseudolymphoma
Systemic Lupus Erythematosus
Young Adult
Lymphoma
Differential Diagnosis
Staining and Labeling

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology
  • Histology

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Characteristic Distribution Pattern of CD30-positive Cytotoxic T Cells Aids Diagnosis of Kikuchi-Fujimoto Disease. / Tabata, Tetsuya; Takata, Katsuyoshi; Miyata-Takata, Tomoko; Sato, Yasuharu; Ishizawa, Shin; Kunitomo, Tomoyoshi; Nagakita, Keina; Ohnishi, Nobuhiko; Taniguchi, Kouhei; Noujima-Harada, Mai; Maeda, Yoshinobu; Tanimoto, Mitsune; Yoshino, Tadashi.

In: Applied Immunohistochemistry and Molecular Morphology, 06.07.2016.

Research output: Contribution to journalArticle

Tabata, Tetsuya ; Takata, Katsuyoshi ; Miyata-Takata, Tomoko ; Sato, Yasuharu ; Ishizawa, Shin ; Kunitomo, Tomoyoshi ; Nagakita, Keina ; Ohnishi, Nobuhiko ; Taniguchi, Kouhei ; Noujima-Harada, Mai ; Maeda, Yoshinobu ; Tanimoto, Mitsune ; Yoshino, Tadashi. / Characteristic Distribution Pattern of CD30-positive Cytotoxic T Cells Aids Diagnosis of Kikuchi-Fujimoto Disease. In: Applied Immunohistochemistry and Molecular Morphology. 2016.
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abstract = "INTRODUCTION:: Histiocytic necrotizing lymphadenitis (or Kikuchi-Fujimoto disease) frequently occurs in Asian young adult females and typically presents as cervical lymphadenopathy with unknown etiology. Although large immunoblasts frequently appear in Kikuchi-Fujimoto disease, the diffuse infiltration of these cells can cause difficulty in establishing a differential diagnosis from lymphoma. In such cases, CD30 immunostaining may be used; however, the extent or distribution pattern of CD30-positive cells in Kikuchi-Fujimoto disease remains largely unknown. Here we investigated the expression of CD30 and its clinicopathologic significance. MATERIALS AND METHODS:: We investigated 30 Kikuchi-Fujimoto disease and 16 control [6, systemic lupus erythematosus (SLE); 10, reactive lymphoid hyperplasia (RLH)] cases. RESULTS:: The number of CD30-positive cells in Kikuchi-Fujimoto disease was significantly more than that in SLE and RLH, and majority of these cells were located around necrotic areas. Moreover, double immunohistochemical staining showed these CD30-positive cells to be CD8-positive cytotoxic T cells, suggesting that activated cytotoxic T cells around necrotic areas are a characteristic feature of this disease. Clinicopathologic analysis showed that cases with abundant CD30-positive cells were predominantly female with only mild symptoms and normal laboratory data. CONCLUSIONS:: In Kikuchi-Fujimoto disease cases, CD30-positive cytotoxic T cells were abundant around necrotic areas; this histologic feature may be helpful to differentiate this disease from SLE and RLH.",
author = "Tetsuya Tabata and Katsuyoshi Takata and Tomoko Miyata-Takata and Yasuharu Sato and Shin Ishizawa and Tomoyoshi Kunitomo and Keina Nagakita and Nobuhiko Ohnishi and Kouhei Taniguchi and Mai Noujima-Harada and Yoshinobu Maeda and Mitsune Tanimoto and Tadashi Yoshino",
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AU - Tabata, Tetsuya

AU - Takata, Katsuyoshi

AU - Miyata-Takata, Tomoko

AU - Sato, Yasuharu

AU - Ishizawa, Shin

AU - Kunitomo, Tomoyoshi

AU - Nagakita, Keina

AU - Ohnishi, Nobuhiko

AU - Taniguchi, Kouhei

AU - Noujima-Harada, Mai

AU - Maeda, Yoshinobu

AU - Tanimoto, Mitsune

AU - Yoshino, Tadashi

PY - 2016/7/6

Y1 - 2016/7/6

N2 - INTRODUCTION:: Histiocytic necrotizing lymphadenitis (or Kikuchi-Fujimoto disease) frequently occurs in Asian young adult females and typically presents as cervical lymphadenopathy with unknown etiology. Although large immunoblasts frequently appear in Kikuchi-Fujimoto disease, the diffuse infiltration of these cells can cause difficulty in establishing a differential diagnosis from lymphoma. In such cases, CD30 immunostaining may be used; however, the extent or distribution pattern of CD30-positive cells in Kikuchi-Fujimoto disease remains largely unknown. Here we investigated the expression of CD30 and its clinicopathologic significance. MATERIALS AND METHODS:: We investigated 30 Kikuchi-Fujimoto disease and 16 control [6, systemic lupus erythematosus (SLE); 10, reactive lymphoid hyperplasia (RLH)] cases. RESULTS:: The number of CD30-positive cells in Kikuchi-Fujimoto disease was significantly more than that in SLE and RLH, and majority of these cells were located around necrotic areas. Moreover, double immunohistochemical staining showed these CD30-positive cells to be CD8-positive cytotoxic T cells, suggesting that activated cytotoxic T cells around necrotic areas are a characteristic feature of this disease. Clinicopathologic analysis showed that cases with abundant CD30-positive cells were predominantly female with only mild symptoms and normal laboratory data. CONCLUSIONS:: In Kikuchi-Fujimoto disease cases, CD30-positive cytotoxic T cells were abundant around necrotic areas; this histologic feature may be helpful to differentiate this disease from SLE and RLH.

AB - INTRODUCTION:: Histiocytic necrotizing lymphadenitis (or Kikuchi-Fujimoto disease) frequently occurs in Asian young adult females and typically presents as cervical lymphadenopathy with unknown etiology. Although large immunoblasts frequently appear in Kikuchi-Fujimoto disease, the diffuse infiltration of these cells can cause difficulty in establishing a differential diagnosis from lymphoma. In such cases, CD30 immunostaining may be used; however, the extent or distribution pattern of CD30-positive cells in Kikuchi-Fujimoto disease remains largely unknown. Here we investigated the expression of CD30 and its clinicopathologic significance. MATERIALS AND METHODS:: We investigated 30 Kikuchi-Fujimoto disease and 16 control [6, systemic lupus erythematosus (SLE); 10, reactive lymphoid hyperplasia (RLH)] cases. RESULTS:: The number of CD30-positive cells in Kikuchi-Fujimoto disease was significantly more than that in SLE and RLH, and majority of these cells were located around necrotic areas. Moreover, double immunohistochemical staining showed these CD30-positive cells to be CD8-positive cytotoxic T cells, suggesting that activated cytotoxic T cells around necrotic areas are a characteristic feature of this disease. Clinicopathologic analysis showed that cases with abundant CD30-positive cells were predominantly female with only mild symptoms and normal laboratory data. CONCLUSIONS:: In Kikuchi-Fujimoto disease cases, CD30-positive cytotoxic T cells were abundant around necrotic areas; this histologic feature may be helpful to differentiate this disease from SLE and RLH.

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