Characteristic diffusion tensor tractography in multiple system atrophy with predominant cerebellar ataxia and cortical cerebellar atrophy

Yusuke Fukui, Nozomi Hishikawa, Kota Sato, Yumiko Nakano, Ryuta Morihara, Yasuyuki Ohta, Toru Yamashita, Koji Abe

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The objective of this study is to determine whether diffusion tensor imaging (DTI) tractography analysis is a potential method for differentiating cerebellar ataxia patients with multiple system atrophy with predominant cerebellar ataxia (MSA-C) and cortical cerebellar atrophy (CCA). Forty-one MSA-C patients (62.7 ± 8.1 years old, mean ± SD) and age- and gender-matched 15 CCA patients (63.0 ± 8.6 years old) were examined. Tractography was performed using the DTI track module provided in the MedINRIA version 1.9.4, and regions of interest were drawn manually to reconstruct an efferent fiber tract and two afferent fiber tracts via the cerebellum. Compared with CCA, MSA-C patients showed significant declines of fractional anisotropy (FA) values of afferent 1 and 2 (p <0.01, respectively) and a significant increase of the radial diffusivity (RD) value in afferent 1 (p <0.05). Receiver-operator characteristic curve analysis showed 85.7 % sensitivity and 75.0 % specificity of FA values in afferent 1 (cutoff value 0.476). Linear regressions showed strong correlations between FA value and disease duration in CCA patients (efferent 1, r = −0.466; afferent 2, r = −0.543; both p <0.05), and between the FA value and the ratio of the standardized scale for the assessment and rating of ataxia (SARA)/disease duration in MSA-C patients (afferent 1, r = −0.407; p <0.01). The present DTI tractography newly showed that the FA values of two afferent fiber tracts showed significant declines in MSA-C patients, and afferent 1 showed good diagnostic sensitivity and specificity. When combining the FA values of efferent 1 with disease duration, the present DTI tractography analysis could be useful for differentiating MSA-C and CCA patients.

Original languageEnglish
JournalJournal of Neurology
DOIs
Publication statusAccepted/In press - Oct 17 2015

Fingerprint

Multiple System Atrophy
Cerebellar Ataxia
Diffusion Tensor Imaging
Atrophy
Anisotropy
Sensitivity and Specificity
Ataxia
Cerebellum
Linear Models

Keywords

  • Cerebellar ataxia
  • Cortical cerebellar atrophy
  • Diffusion tensor imaging
  • Multiple system atrophy
  • Olivopontocerebellar atrophy
  • Tractography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

@article{9006d77a239d4fd293ac0cb8d73d15d8,
title = "Characteristic diffusion tensor tractography in multiple system atrophy with predominant cerebellar ataxia and cortical cerebellar atrophy",
abstract = "The objective of this study is to determine whether diffusion tensor imaging (DTI) tractography analysis is a potential method for differentiating cerebellar ataxia patients with multiple system atrophy with predominant cerebellar ataxia (MSA-C) and cortical cerebellar atrophy (CCA). Forty-one MSA-C patients (62.7 ± 8.1 years old, mean ± SD) and age- and gender-matched 15 CCA patients (63.0 ± 8.6 years old) were examined. Tractography was performed using the DTI track module provided in the MedINRIA version 1.9.4, and regions of interest were drawn manually to reconstruct an efferent fiber tract and two afferent fiber tracts via the cerebellum. Compared with CCA, MSA-C patients showed significant declines of fractional anisotropy (FA) values of afferent 1 and 2 (p <0.01, respectively) and a significant increase of the radial diffusivity (RD) value in afferent 1 (p <0.05). Receiver-operator characteristic curve analysis showed 85.7 {\%} sensitivity and 75.0 {\%} specificity of FA values in afferent 1 (cutoff value 0.476). Linear regressions showed strong correlations between FA value and disease duration in CCA patients (efferent 1, r = −0.466; afferent 2, r = −0.543; both p <0.05), and between the FA value and the ratio of the standardized scale for the assessment and rating of ataxia (SARA)/disease duration in MSA-C patients (afferent 1, r = −0.407; p <0.01). The present DTI tractography newly showed that the FA values of two afferent fiber tracts showed significant declines in MSA-C patients, and afferent 1 showed good diagnostic sensitivity and specificity. When combining the FA values of efferent 1 with disease duration, the present DTI tractography analysis could be useful for differentiating MSA-C and CCA patients.",
keywords = "Cerebellar ataxia, Cortical cerebellar atrophy, Diffusion tensor imaging, Multiple system atrophy, Olivopontocerebellar atrophy, Tractography",
author = "Yusuke Fukui and Nozomi Hishikawa and Kota Sato and Yumiko Nakano and Ryuta Morihara and Yasuyuki Ohta and Toru Yamashita and Koji Abe",
year = "2015",
month = "10",
day = "17",
doi = "10.1007/s00415-015-7934-x",
language = "English",
journal = "Journal of Neurology",
issn = "0340-5354",
publisher = "D. Steinkopff-Verlag",

}

TY - JOUR

T1 - Characteristic diffusion tensor tractography in multiple system atrophy with predominant cerebellar ataxia and cortical cerebellar atrophy

AU - Fukui, Yusuke

AU - Hishikawa, Nozomi

AU - Sato, Kota

AU - Nakano, Yumiko

AU - Morihara, Ryuta

AU - Ohta, Yasuyuki

AU - Yamashita, Toru

AU - Abe, Koji

PY - 2015/10/17

Y1 - 2015/10/17

N2 - The objective of this study is to determine whether diffusion tensor imaging (DTI) tractography analysis is a potential method for differentiating cerebellar ataxia patients with multiple system atrophy with predominant cerebellar ataxia (MSA-C) and cortical cerebellar atrophy (CCA). Forty-one MSA-C patients (62.7 ± 8.1 years old, mean ± SD) and age- and gender-matched 15 CCA patients (63.0 ± 8.6 years old) were examined. Tractography was performed using the DTI track module provided in the MedINRIA version 1.9.4, and regions of interest were drawn manually to reconstruct an efferent fiber tract and two afferent fiber tracts via the cerebellum. Compared with CCA, MSA-C patients showed significant declines of fractional anisotropy (FA) values of afferent 1 and 2 (p <0.01, respectively) and a significant increase of the radial diffusivity (RD) value in afferent 1 (p <0.05). Receiver-operator characteristic curve analysis showed 85.7 % sensitivity and 75.0 % specificity of FA values in afferent 1 (cutoff value 0.476). Linear regressions showed strong correlations between FA value and disease duration in CCA patients (efferent 1, r = −0.466; afferent 2, r = −0.543; both p <0.05), and between the FA value and the ratio of the standardized scale for the assessment and rating of ataxia (SARA)/disease duration in MSA-C patients (afferent 1, r = −0.407; p <0.01). The present DTI tractography newly showed that the FA values of two afferent fiber tracts showed significant declines in MSA-C patients, and afferent 1 showed good diagnostic sensitivity and specificity. When combining the FA values of efferent 1 with disease duration, the present DTI tractography analysis could be useful for differentiating MSA-C and CCA patients.

AB - The objective of this study is to determine whether diffusion tensor imaging (DTI) tractography analysis is a potential method for differentiating cerebellar ataxia patients with multiple system atrophy with predominant cerebellar ataxia (MSA-C) and cortical cerebellar atrophy (CCA). Forty-one MSA-C patients (62.7 ± 8.1 years old, mean ± SD) and age- and gender-matched 15 CCA patients (63.0 ± 8.6 years old) were examined. Tractography was performed using the DTI track module provided in the MedINRIA version 1.9.4, and regions of interest were drawn manually to reconstruct an efferent fiber tract and two afferent fiber tracts via the cerebellum. Compared with CCA, MSA-C patients showed significant declines of fractional anisotropy (FA) values of afferent 1 and 2 (p <0.01, respectively) and a significant increase of the radial diffusivity (RD) value in afferent 1 (p <0.05). Receiver-operator characteristic curve analysis showed 85.7 % sensitivity and 75.0 % specificity of FA values in afferent 1 (cutoff value 0.476). Linear regressions showed strong correlations between FA value and disease duration in CCA patients (efferent 1, r = −0.466; afferent 2, r = −0.543; both p <0.05), and between the FA value and the ratio of the standardized scale for the assessment and rating of ataxia (SARA)/disease duration in MSA-C patients (afferent 1, r = −0.407; p <0.01). The present DTI tractography newly showed that the FA values of two afferent fiber tracts showed significant declines in MSA-C patients, and afferent 1 showed good diagnostic sensitivity and specificity. When combining the FA values of efferent 1 with disease duration, the present DTI tractography analysis could be useful for differentiating MSA-C and CCA patients.

KW - Cerebellar ataxia

KW - Cortical cerebellar atrophy

KW - Diffusion tensor imaging

KW - Multiple system atrophy

KW - Olivopontocerebellar atrophy

KW - Tractography

UR - http://www.scopus.com/inward/record.url?scp=84945242583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945242583&partnerID=8YFLogxK

U2 - 10.1007/s00415-015-7934-x

DO - 10.1007/s00415-015-7934-x

M3 - Article

C2 - 26477028

AN - SCOPUS:84955671629

JO - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

ER -