Changes of pre-Sl and pre-S2 antigens in sera of patients with hepatitis B virus infection

Yoshiaki Iwasaki, Kazuharu Matsuura, Takao Tsuji

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Polypeptides encoded by the pre-Sl and pre-S2 genes of hepatitis B virus (HBV) (pre-Sl antigen and pre-S2 antigen) were detected by enzyme-linked immunosorbent assay (ELISA) in 137 serum samples of patients with HBV infection. The HBV-DNA level closely correlated with the titer of pre-S antigens. However, HBV-DNA levels more closely correlated with the titer of the pre-Sl antigen [HBV-asymptomatic carrier (ASC): n=40, r=0.800, P 200 IU/L] and the ALT level normalized, were followed for 12 months and classified into two groups: Group 1, those in whom HBeAg reappeared with an elevated ALT level within 12 months, and Group 2, those in whom HBeAg was persistently cleared from the serum and a normal ALT level continued. Of the 30 patients, 24 (80%) were classifed into Group 1 and 6 (20%) were classified into Group 2. Changes in serum levels of HBV markers a month before and after AE were observed. The HBV-DNA level and DNA-P activity became negative after AE in both groups. The titer of pre-Sl antigen also decreased after AE, and no significant differences were observed between Group 1 and Group 2. In contrast, the titer of pre-82 antigen and pAR activity decreased more significantly in Group 2 than in Group 1. These results suggest that the detection of the pre-S2 antigen and pAR activity in sera seems to be more useful as a prognostic test for patients with HBV infection than the detection of pre-Sl antigen, HBV-DNA, DNA-P or HBeAg.

Original languageEnglish
Pages (from-to)451-457
Number of pages7
JournalGastroenterologia Japonica
Volume25
Issue number4
DOIs
Publication statusPublished - Aug 1990

Fingerprint

Virus Diseases
Hepatitis B virus
Antigens
Serum
Hepatitis B e Antigens
DNA
Enzyme-Linked Immunosorbent Assay
Peptides

Keywords

  • hepatitis B virus
  • polymerized human serum albumin receptor
  • pre-S2 antigen
  • pre-Sl antigen
  • seroconversion to anti-HBe

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Changes of pre-Sl and pre-S2 antigens in sera of patients with hepatitis B virus infection. / Iwasaki, Yoshiaki; Matsuura, Kazuharu; Tsuji, Takao.

In: Gastroenterologia Japonica, Vol. 25, No. 4, 08.1990, p. 451-457.

Research output: Contribution to journalArticle

@article{2a388769e54f443e86859c04a7782f85,
title = "Changes of pre-Sl and pre-S2 antigens in sera of patients with hepatitis B virus infection",
abstract = "Polypeptides encoded by the pre-Sl and pre-S2 genes of hepatitis B virus (HBV) (pre-Sl antigen and pre-S2 antigen) were detected by enzyme-linked immunosorbent assay (ELISA) in 137 serum samples of patients with HBV infection. The HBV-DNA level closely correlated with the titer of pre-S antigens. However, HBV-DNA levels more closely correlated with the titer of the pre-Sl antigen [HBV-asymptomatic carrier (ASC): n=40, r=0.800, P 200 IU/L] and the ALT level normalized, were followed for 12 months and classified into two groups: Group 1, those in whom HBeAg reappeared with an elevated ALT level within 12 months, and Group 2, those in whom HBeAg was persistently cleared from the serum and a normal ALT level continued. Of the 30 patients, 24 (80{\%}) were classifed into Group 1 and 6 (20{\%}) were classified into Group 2. Changes in serum levels of HBV markers a month before and after AE were observed. The HBV-DNA level and DNA-P activity became negative after AE in both groups. The titer of pre-Sl antigen also decreased after AE, and no significant differences were observed between Group 1 and Group 2. In contrast, the titer of pre-82 antigen and pAR activity decreased more significantly in Group 2 than in Group 1. These results suggest that the detection of the pre-S2 antigen and pAR activity in sera seems to be more useful as a prognostic test for patients with HBV infection than the detection of pre-Sl antigen, HBV-DNA, DNA-P or HBeAg.",
keywords = "hepatitis B virus, polymerized human serum albumin receptor, pre-S2 antigen, pre-Sl antigen, seroconversion to anti-HBe",
author = "Yoshiaki Iwasaki and Kazuharu Matsuura and Takao Tsuji",
year = "1990",
month = "8",
doi = "10.1007/BF02779333",
language = "English",
volume = "25",
pages = "451--457",
journal = "Journal of Gastroenterology",
issn = "0944-1174",
publisher = "Springer Japan",
number = "4",

}

TY - JOUR

T1 - Changes of pre-Sl and pre-S2 antigens in sera of patients with hepatitis B virus infection

AU - Iwasaki, Yoshiaki

AU - Matsuura, Kazuharu

AU - Tsuji, Takao

PY - 1990/8

Y1 - 1990/8

N2 - Polypeptides encoded by the pre-Sl and pre-S2 genes of hepatitis B virus (HBV) (pre-Sl antigen and pre-S2 antigen) were detected by enzyme-linked immunosorbent assay (ELISA) in 137 serum samples of patients with HBV infection. The HBV-DNA level closely correlated with the titer of pre-S antigens. However, HBV-DNA levels more closely correlated with the titer of the pre-Sl antigen [HBV-asymptomatic carrier (ASC): n=40, r=0.800, P 200 IU/L] and the ALT level normalized, were followed for 12 months and classified into two groups: Group 1, those in whom HBeAg reappeared with an elevated ALT level within 12 months, and Group 2, those in whom HBeAg was persistently cleared from the serum and a normal ALT level continued. Of the 30 patients, 24 (80%) were classifed into Group 1 and 6 (20%) were classified into Group 2. Changes in serum levels of HBV markers a month before and after AE were observed. The HBV-DNA level and DNA-P activity became negative after AE in both groups. The titer of pre-Sl antigen also decreased after AE, and no significant differences were observed between Group 1 and Group 2. In contrast, the titer of pre-82 antigen and pAR activity decreased more significantly in Group 2 than in Group 1. These results suggest that the detection of the pre-S2 antigen and pAR activity in sera seems to be more useful as a prognostic test for patients with HBV infection than the detection of pre-Sl antigen, HBV-DNA, DNA-P or HBeAg.

AB - Polypeptides encoded by the pre-Sl and pre-S2 genes of hepatitis B virus (HBV) (pre-Sl antigen and pre-S2 antigen) were detected by enzyme-linked immunosorbent assay (ELISA) in 137 serum samples of patients with HBV infection. The HBV-DNA level closely correlated with the titer of pre-S antigens. However, HBV-DNA levels more closely correlated with the titer of the pre-Sl antigen [HBV-asymptomatic carrier (ASC): n=40, r=0.800, P 200 IU/L] and the ALT level normalized, were followed for 12 months and classified into two groups: Group 1, those in whom HBeAg reappeared with an elevated ALT level within 12 months, and Group 2, those in whom HBeAg was persistently cleared from the serum and a normal ALT level continued. Of the 30 patients, 24 (80%) were classifed into Group 1 and 6 (20%) were classified into Group 2. Changes in serum levels of HBV markers a month before and after AE were observed. The HBV-DNA level and DNA-P activity became negative after AE in both groups. The titer of pre-Sl antigen also decreased after AE, and no significant differences were observed between Group 1 and Group 2. In contrast, the titer of pre-82 antigen and pAR activity decreased more significantly in Group 2 than in Group 1. These results suggest that the detection of the pre-S2 antigen and pAR activity in sera seems to be more useful as a prognostic test for patients with HBV infection than the detection of pre-Sl antigen, HBV-DNA, DNA-P or HBeAg.

KW - hepatitis B virus

KW - polymerized human serum albumin receptor

KW - pre-S2 antigen

KW - pre-Sl antigen

KW - seroconversion to anti-HBe

UR - http://www.scopus.com/inward/record.url?scp=0025182176&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025182176&partnerID=8YFLogxK

U2 - 10.1007/BF02779333

DO - 10.1007/BF02779333

M3 - Article

C2 - 2170220

AN - SCOPUS:0025182176

VL - 25

SP - 451

EP - 457

JO - Journal of Gastroenterology

JF - Journal of Gastroenterology

SN - 0944-1174

IS - 4

ER -