Changes of neuropeptides and their receptors in experimental stroke gerbil brains

Kumiko Haba, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Yukiko H. Sora, Akitane Mori

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Eight kinds of neuropeptides and four kinds of neuropeptide receptors were examined in the right and left hemispheres of mongolian gerbils after unilateral carotid ligation-induced stroke and in normal controls. Five hours after ligation of the right common carotid artery, β-endorphin concentration in the right hemisphere (ischemic side) of the stroke group was significantly increased compared with that in the contralateral hemisphere (non-ischemic side), but there were no differences between sides in other neuropeptides either with or without stroke. Furthermore, although there were no differences in [3H]naloxone binding, [3H]thyrotropin-releasing hormone binding or 125I-vasoactive intestinal polypeptide binding in the brain in this model of stroke, [3H]enkephalin binding was significantly lower on the ischemic side than on the non-ischemic side in the stroke group. These results suggest that increased activity in the β-endorphinergic system in the brain might be partly caused by ischemic brain failure.

Original languageEnglish
Pages (from-to)88-92
Number of pages5
JournalJournal of the neurological sciences
Volume108
Issue number1
DOIs
Publication statusPublished - Mar 1992

Keywords

  • Mongolian gerbil
  • Neuropeptide
  • Neuropeptide receptor
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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