Changes in the proportions of bronchoalveolar lymphocytes, neutrophils and basophilic cells and the release of histamine and leukotrienes from bronchoalveolar cells in patients with steroid-dependent intractable asthma

Yoshiro Tanizaki, Hikaru Kitani, Morihiro Okazaki, Takashi Mifune, Fumihiro Mitsunobu, Ikuro Kimura

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The proportion of inflammatory cells in bronchoalveolar lavage (BAL) fluid and the release of chemical mediators from BAL and peripheral blood cells were examined in 40 patients with steroid-dependent intractable asthma (SDIA) to clarify the effects of a long-term glucocorticoid regimen on these cells. The proportion of BAL lymphocytes was significantly reduced (p < 0.01) and the proportion of BAL neutrophils was significantly increased (p <0.01) in SDIA patients compared with non-SDIA patients. The proportion of basophilic cells (mast cells and basophils) in BAL fluid was significantly lower in SDIA patients compared to non-SDIA patients (p <0.02). The values of six ventilatory parameters were significantly lower in SDIA patients with a high proportion of BAL neutrophils (more than 10%) compared with the values in non-SDIA patients. The release of histamine and leukotriene C4 (LTC4) from the BAL cells of patients with atopic asthma was significantly reduced in SDIA patients compared with non-SDIA patients (p <0.05). These results show that the changes in the proportion of BAL cells are observed in patients with SDIA. and these changes arc related to suppressed ventilatory function and a reduction in the release of histamine and LTC4 from BAL cells.

Original languageEnglish
Pages (from-to)196-202
Number of pages7
JournalInternational Archives of Allergy and Immunology
Volume101
Issue number2
DOIs
Publication statusPublished - Jan 1 1993
Externally publishedYes

Keywords

  • Bronchoalveolar lavage fluid
  • Histamine
  • Leukotriene C<inf>4</inf>
  • Long-term glucocorticoid regimen
  • Ventilatory function

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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