Isolated and purified glomerular basement membranes (GBM) of normal and aminonucleoside (PAN) nephrotic rats were observed by electron microscopy after negative staining. Although GBM of normal rats appeared as a molecular sieve with uniform pores, GBM of nephrotic rats showed enlargement and elongation of the pores. For an average of fifty pores, the long dimension was 40.4 ± 10.7 Å and the short dimension 13.8 ± 3.6 Å in nephrosis whereas the long dimension was 12.3 ± 2.5 Å and the short dimension 8.4 ± 1.0 Å in normal rats. Changes in the pores in GBM were thought to result in increased permeability of serum protein and hence proteinuria.
|Number of pages||4|
|Journal||Acta medica Okayama|
|Publication status||Published - Dec 1 1980|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)