Changes in the molecular sieve of glomerular basement membrane in rats with aminonucleoside nephrosis

Y. Takaya, Z. Ota, H. Makino, K. Kida, A. Miyoshi, M. Hiramatsu, K. Takahashi, T. Ofuji

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Isolated and purified glomerular basement membranes (GBM) of normal and aminonucleoside (PAN) nephrotic rats were observed by electron microscopy after negative staining. Although GBM of normal rats appeared as a molecular sieve with uniform pores, GBM of nephrotic rats showed enlargement and elongation of the pores. For an average of fifty pores, the long dimension was 40.4 ± 10.7 Å and the short dimension 13.8 ± 3.6 Å in nephrosis whereas the long dimension was 12.3 ± 2.5 Å and the short dimension 8.4 ± 1.0 Å in normal rats. Changes in the pores in GBM were thought to result in increased permeability of serum protein and hence proteinuria.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalActa medica Okayama
Issue number1
Publication statusPublished - Dec 1 1980


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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