Changes in serum concentrations of matrix metalloproteinases, tissue inhibitors of metalloproteinases and type IV collagen in patients with various types of glomerulonephritis

Kenji Akiyama, Kenichi Shikata, Hikaru Sugimoto, Mitsuhiro Matsuda, Yasushi Shikata, Noboru Fujimoto, Kenichi Obata, Hideki Matsui, Hirofumi Makino

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

One of the major causes of glomerular sclerosis which precedes renal failure is an increase in glomerular extracellular matrices (ECMs). Glomerular ECMs which are composed of mesangial matrix and basement membrane play an important role in physical, mechanical and structural functions of the glomerulus. Matrix metalloproteinases (MMPs) are the enzymes which degrade both the collagenous and noncollagenous components of the ECMs. Tissue inhibitors of metalloproteinases (TIMPs) are inhibitors of MMPs. The regulations by MMPs and TIMPs are considered to contribute to maintain homeostasis in the production and degradation of ECMs in the glomeruli. In the glomeruli of patients with glomerulonephritis, the imbalance between production and degradation of ECMs is supposed to cause the increase in ECMs and glomerular sclerosis. In this study, serum concentrations of MMP-1, -2, and -3, TIMP-1 and 2 and type IV collagen were measured in patients with IgA nephropathy, lupus nephritis and membranous nephropathy. In patients with IgA nephropathy and lupus nephritis which are mesangial proliferative glomerulonephritis, the levels of MMP-3 and TIMP-2 were increased. On the other hand, the levels of type IV collagen, MMP-2 and TIMP-1 were increased in patients with membranous nephropathy in which the thickening of basement membrane is characteristic. These differences may be caused by the difference of the pathogenesis of these diseases. The present results suggest that the imbalance between the metabolism of ECMs occurs in patients with glomerulonephritis and contributes to the progression of glomerulonephritis.

Original languageEnglish
Pages (from-to)115-128
Number of pages14
JournalResearch Communications in Molecular Pathology and Pharmacology
Volume95
Issue number2
Publication statusPublished - 1997

Fingerprint

Tissue Inhibitor of Metalloproteinases
Matrix Metalloproteinase Inhibitors
Collagen Type IV
Glomerulonephritis
Extracellular Matrix
Serum
Tissue Inhibitor of Metalloproteinase-2
Membranous Glomerulonephritis
Lupus Nephritis
Tissue Inhibitor of Metalloproteinase-1
Matrix Metalloproteinase 2
Sclerosis
Basement Membrane
Immunoglobulin A
Matrix Metalloproteinase 3
Matrix Metalloproteinase 1
Matrix Metalloproteinases
Renal Insufficiency
Homeostasis
Enzymes

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pathology and Forensic Medicine

Cite this

Changes in serum concentrations of matrix metalloproteinases, tissue inhibitors of metalloproteinases and type IV collagen in patients with various types of glomerulonephritis. / Akiyama, Kenji; Shikata, Kenichi; Sugimoto, Hikaru; Matsuda, Mitsuhiro; Shikata, Yasushi; Fujimoto, Noboru; Obata, Kenichi; Matsui, Hideki; Makino, Hirofumi.

In: Research Communications in Molecular Pathology and Pharmacology, Vol. 95, No. 2, 1997, p. 115-128.

Research output: Contribution to journalArticle

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