Changes in monoamine turnover in the brain of cachectic mice bearing Colon-26 tumor cells

Masashi Uomoto, Masahiro Nishibori, Naoki Nakaya, Yoshiaki Takeuchi, Hiromi Iwagaki, Noriaki Tanaka, Kiyomi Saeki

Research output: Contribution to journalArticle

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Abstract

Patients with cancer cachexia often suffer from psychiatric disorders. In the present study, we investigated the changes in monoaminergic activities in the brain in tumor-bearing mice with reference to the development of cachexia. Two clones, clone-5 (noncachectic clone) and clone-20 (cachectic clone), derived from the murine Colon-26 adenocarcinoma cell line (Nippon Roche Research Center), were inoculated subcutaneously at 1 x 106 cells/0.2 ml into the right lower back of BALB/c mice. In clone-20 mice, body weight and locomotor activity decreased significantly 10-15 days after tumor inoculation. The levels of noradrenaline, dopamine, and 3,4- dihydroxyphenylacetic acid showed no significant change among the three groups. The noradrenaline turnover rate in clone-20 mice was increased in cerebral cortex, hypothalamus, and midbrain. The 5-hydroxytryptamine turnover rate in clone-20 mice was increased in hippocampus, cerebral cortex, midbrain, and pons-medulla oblongata. In contrast, the dopamine turnover rate in clone-20 mice was decreased markedly in hippocampus, cerebral cortex, striatum, hypothalamus, and cerebellum. There was no significant change in amine turnover between control and clone-5 mice except for dopamine in hippocampus, cerebral cortex, and striatum and 5-hydroxytryptamine in striatum. No significant change in the levels of amino acids in the brain was observed among the three groups of mice. It is concluded that some of the psychiatric disorders from which cancer cachectic patients suffer might be ascribable to changes in monoaminergic activities in the brain.

Original languageEnglish
Pages (from-to)260-267
Number of pages8
JournalJournal of Neurochemistry
Volume70
Issue number1
Publication statusPublished - Jan 1998

Fingerprint

Bearings (structural)
Tumors
Dopamine
Brain
Colon
Clone Cells
Cells
Serotonin
Norepinephrine
3,4-Dihydroxyphenylacetic Acid
Neoplasms
Cerebral Cortex
Amines
Hippocampus
Cachexia
Amino Acids
Mesencephalon
Hypothalamus
Psychiatry
Medulla Oblongata

Keywords

  • Affective disorders in cancer patients
  • Cancer cachexia
  • Colon-26
  • Monoamine turnover
  • Palliative therapy
  • Psychooncology

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Uomoto, M., Nishibori, M., Nakaya, N., Takeuchi, Y., Iwagaki, H., Tanaka, N., & Saeki, K. (1998). Changes in monoamine turnover in the brain of cachectic mice bearing Colon-26 tumor cells. Journal of Neurochemistry, 70(1), 260-267.

Changes in monoamine turnover in the brain of cachectic mice bearing Colon-26 tumor cells. / Uomoto, Masashi; Nishibori, Masahiro; Nakaya, Naoki; Takeuchi, Yoshiaki; Iwagaki, Hiromi; Tanaka, Noriaki; Saeki, Kiyomi.

In: Journal of Neurochemistry, Vol. 70, No. 1, 01.1998, p. 260-267.

Research output: Contribution to journalArticle

Uomoto, M, Nishibori, M, Nakaya, N, Takeuchi, Y, Iwagaki, H, Tanaka, N & Saeki, K 1998, 'Changes in monoamine turnover in the brain of cachectic mice bearing Colon-26 tumor cells', Journal of Neurochemistry, vol. 70, no. 1, pp. 260-267.
Uomoto M, Nishibori M, Nakaya N, Takeuchi Y, Iwagaki H, Tanaka N et al. Changes in monoamine turnover in the brain of cachectic mice bearing Colon-26 tumor cells. Journal of Neurochemistry. 1998 Jan;70(1):260-267.
Uomoto, Masashi ; Nishibori, Masahiro ; Nakaya, Naoki ; Takeuchi, Yoshiaki ; Iwagaki, Hiromi ; Tanaka, Noriaki ; Saeki, Kiyomi. / Changes in monoamine turnover in the brain of cachectic mice bearing Colon-26 tumor cells. In: Journal of Neurochemistry. 1998 ; Vol. 70, No. 1. pp. 260-267.
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