Abstract
In order to clarify the mechanism of the antidepressive effects of trazodone, a selective serotonin reuptake inhibitor, we investigated the dynamics of monoamine metabolites in cerebrospinal fluid (CSF) of free-moving conscious rats by acute and long-term treatment with trazodone. When 100 mg kg-1 p.o. of trazodone were administered, a significant increase of 3-methoxy-4-hydroxyphenylglycol (MHPG) concentration was soon observed in the light period of the light/dark cycle, and a significant decrease of dihydroxy phenyl acetic acid (DOPAC) concentration was observed during the 2 days after administration of trazodone; in contrast, the homovanilic acid (HVA) level was increased. However, we detected no significant changes in the 5-hydroxy indole-3-acetic acid (5-HIAA) concentration during the 3 days. In the case of long-term treatment with 50 mg kg-1, p.o. of trazodone, the levels of MHPG, DOPAC and HVA exhibited no difference when compared with values obtained during saline treatment in either the light or dark period, whereas the levels of 5-HIAA showed a significant increase during the light period. These findings suggest that a long-term treatment with trazodone enhances the serotonergic neurons.
| Original language | English |
|---|---|
| Pages (from-to) | 503-508 |
| Number of pages | 6 |
| Journal | Pharmacological Research |
| Volume | 40 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 1999 |
| Externally published | Yes |
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Keywords
- Antidepressant
- Cerebrospinal fluid
- Monoamine metabolite
- Selective serotonin reuptake inhibitors
- Trazodone
ASJC Scopus subject areas
- Pharmacology
Cite this
Changes in monoamine metabolites concentrations in rat cerebrospinal fluid after acute and long-term administration of a selective serotonin reuptake inhibitor, trazodone. / Egashira, T.; Takayama, Fusako; Yamanaka, Y.
In: Pharmacological Research, Vol. 40, No. 6, 12.1999, p. 503-508.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in monoamine metabolites concentrations in rat cerebrospinal fluid after acute and long-term administration of a selective serotonin reuptake inhibitor, trazodone
AU - Egashira, T.
AU - Takayama, Fusako
AU - Yamanaka, Y.
PY - 1999/12
Y1 - 1999/12
N2 - In order to clarify the mechanism of the antidepressive effects of trazodone, a selective serotonin reuptake inhibitor, we investigated the dynamics of monoamine metabolites in cerebrospinal fluid (CSF) of free-moving conscious rats by acute and long-term treatment with trazodone. When 100 mg kg-1 p.o. of trazodone were administered, a significant increase of 3-methoxy-4-hydroxyphenylglycol (MHPG) concentration was soon observed in the light period of the light/dark cycle, and a significant decrease of dihydroxy phenyl acetic acid (DOPAC) concentration was observed during the 2 days after administration of trazodone; in contrast, the homovanilic acid (HVA) level was increased. However, we detected no significant changes in the 5-hydroxy indole-3-acetic acid (5-HIAA) concentration during the 3 days. In the case of long-term treatment with 50 mg kg-1, p.o. of trazodone, the levels of MHPG, DOPAC and HVA exhibited no difference when compared with values obtained during saline treatment in either the light or dark period, whereas the levels of 5-HIAA showed a significant increase during the light period. These findings suggest that a long-term treatment with trazodone enhances the serotonergic neurons.
AB - In order to clarify the mechanism of the antidepressive effects of trazodone, a selective serotonin reuptake inhibitor, we investigated the dynamics of monoamine metabolites in cerebrospinal fluid (CSF) of free-moving conscious rats by acute and long-term treatment with trazodone. When 100 mg kg-1 p.o. of trazodone were administered, a significant increase of 3-methoxy-4-hydroxyphenylglycol (MHPG) concentration was soon observed in the light period of the light/dark cycle, and a significant decrease of dihydroxy phenyl acetic acid (DOPAC) concentration was observed during the 2 days after administration of trazodone; in contrast, the homovanilic acid (HVA) level was increased. However, we detected no significant changes in the 5-hydroxy indole-3-acetic acid (5-HIAA) concentration during the 3 days. In the case of long-term treatment with 50 mg kg-1, p.o. of trazodone, the levels of MHPG, DOPAC and HVA exhibited no difference when compared with values obtained during saline treatment in either the light or dark period, whereas the levels of 5-HIAA showed a significant increase during the light period. These findings suggest that a long-term treatment with trazodone enhances the serotonergic neurons.
KW - Antidepressant
KW - Cerebrospinal fluid
KW - Monoamine metabolite
KW - Selective serotonin reuptake inhibitors
KW - Trazodone
UR - http://www.scopus.com/inward/record.url?scp=0032763098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032763098&partnerID=8YFLogxK
U2 - 10.1006/phrs.1999.0546
DO - 10.1006/phrs.1999.0546
M3 - Article
C2 - 10660949
AN - SCOPUS:0032763098
VL - 40
SP - 503
EP - 508
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
IS - 6
ER -