Changes in LPIA D-dimer levels after total hip or knee arthroplasty relevant to deep-vein thrombosis diagnosed by bilateral ascending venography

Naofumi Shiota, Toru Sato, Keiichiro Nishida, Masatsugu Matsuo, Yasuhiro Takahara, Shigeru Mitani, Takuro Murakami, Hajime Inoue

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The purpose of the current retrospective study was to determine the most sensitive and specific cutoff value of plasma D-dimer level associated with deep-vein thrombosis (DVT) after total hip (THA) or knee (TKA) joint arthroplasty. Diagnosis of DVT was determined by bilateral ascending venography pre- and postoperatively. Plasma D-dimer levels were measured by a latex photometric immunoassay system (LPIA) preoperatively and postoperatively on days 1, 3, 7, 10, 14, and 21. Postoperative DVT diagnosed by venography was found in 22 patients (40.1%) after THA and in 18 patients (64.3%) after TKA. Plasma D-dimer levels were significantly higher (P <0.01) in patients with DVT than in those without DVT on days 1, 7, and 10 after THA, but only on day 7 after TKA. Statistical analysis confirmed that a cutoff value of 10.0 μg/ml for D-dimer on day 7 was most sensitive (THA, 95.5%; TKA, 94.4%) and most specific (THA, 96.9%; TKA, 90.0%) in the diagnosis of DVT after THA as well as TKA. It was concluded that over 10 μg/ml of LPIA D-dimer on post-operative day 7 appears to be an indication of the occurrence of DVT after THA and TKA.

Original languageEnglish
Pages (from-to)444-450
Number of pages7
JournalJournal of Orthopaedic Science
Volume7
Issue number4
DOIs
Publication statusPublished - 2002

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Tacrine
Knee Replacement Arthroplasties
Phlebography
Latex
Immunoassay
Venous Thrombosis
Hip
Knee Joint
fibrin fragment D
Arthroplasty
Retrospective Studies

Keywords

  • D-dimer
  • Deep-vein thrombosis (DVT)
  • LPIA assay
  • Total joint arthroplasty

ASJC Scopus subject areas

  • Surgery

Cite this

Changes in LPIA D-dimer levels after total hip or knee arthroplasty relevant to deep-vein thrombosis diagnosed by bilateral ascending venography. / Shiota, Naofumi; Sato, Toru; Nishida, Keiichiro; Matsuo, Masatsugu; Takahara, Yasuhiro; Mitani, Shigeru; Murakami, Takuro; Inoue, Hajime.

In: Journal of Orthopaedic Science, Vol. 7, No. 4, 2002, p. 444-450.

Research output: Contribution to journalArticle

Shiota, Naofumi ; Sato, Toru ; Nishida, Keiichiro ; Matsuo, Masatsugu ; Takahara, Yasuhiro ; Mitani, Shigeru ; Murakami, Takuro ; Inoue, Hajime. / Changes in LPIA D-dimer levels after total hip or knee arthroplasty relevant to deep-vein thrombosis diagnosed by bilateral ascending venography. In: Journal of Orthopaedic Science. 2002 ; Vol. 7, No. 4. pp. 444-450.
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