Changes in LPIA D-dimer levels after total hip or knee arthroplasty relevant to deep-vein thrombosis diagnosed by bilateral ascending venography

Naofumi Shiota, Toru Sato, Keiichiro Nishida, Masatsugu Matsuo, Yasuhiro Takahara, Shigeru Mitani, Takuro Murakami, Hajime Inoue

Research output: Contribution to journalArticle

35 Citations (Scopus)


The purpose of the current retrospective study was to determine the most sensitive and specific cutoff value of plasma D-dimer level associated with deep-vein thrombosis (DVT) after total hip (THA) or knee (TKA) joint arthroplasty. Diagnosis of DVT was determined by bilateral ascending venography pre- and postoperatively. Plasma D-dimer levels were measured by a latex photometric immunoassay system (LPIA) preoperatively and postoperatively on days 1, 3, 7, 10, 14, and 21. Postoperative DVT diagnosed by venography was found in 22 patients (40.1%) after THA and in 18 patients (64.3%) after TKA. Plasma D-dimer levels were significantly higher (P < 0.01) in patients with DVT than in those without DVT on days 1, 7, and 10 after THA, but only on day 7 after TKA. Statistical analysis confirmed that a cutoff value of 10.0 μg/ml for D-dimer on day 7 was most sensitive (THA, 95.5%; TKA, 94.4%) and most specific (THA, 96.9%; TKA, 90.0%) in the diagnosis of DVT after THA as well as TKA. It was concluded that over 10 μg/ml of LPIA D-dimer on post-operative day 7 appears to be an indication of the occurrence of DVT after THA and TKA.

Original languageEnglish
Pages (from-to)444-450
Number of pages7
JournalJournal of Orthopaedic Science
Issue number4
Publication statusPublished - Jan 1 2002



  • D-dimer
  • Deep-vein thrombosis (DVT)
  • LPIA assay
  • Total joint arthroplasty

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this