TY - JOUR
T1 - Changes in Histamine Metabolism in the Mouse Hypothalamus Induced by Acute Administration of Ethanol
AU - Itoh, Yoshinori
AU - Nishibori, Masahiro
AU - Oishi, Ryozo
AU - Saeki, Kiyomi
PY - 1985/12
Y1 - 1985/12
N2 - Abstract: The effect of acute ethanol administration on histamine (HA) dynamics was examined in the mouse hypothalamus. The steady‐state level of HA did not change after intraperitoneal administration of ethanol (0.5–5 g/kg), whereas the level of tele‐methylhistamine (t‐MH), a predominant metabolite of brain HA, increased when 3 and 5 g/kg of ethanol was given. Pargyline hydrochloride (80 mg/kg, i.p.) increased the level of t‐MH by 72.2% 90 min after the treatment. Ethanol at any dose given did not significantly affect the t‐MH level in the pargyline‐pretreated mice. Decrease in the t‐MH level induced by metoprine (10 mg/kg, i.p.), an inhibitor of HA‐N‐methyltransferase, was suppressed by ethanol (5 g/kg), thereby suggesting inhibition of the elimination of brain t‐MH. Ethanol (5 g/kg) significantly delayed the depletion of HA induced by (S)‐α‐fluoromethylhistidine (50 mg/kg, i.v.), a specific inhibitor of histidine decarboxylase. Therefore, a large dose of ethanol apparently decreases HA turnover in the mouse hypothalamus.
AB - Abstract: The effect of acute ethanol administration on histamine (HA) dynamics was examined in the mouse hypothalamus. The steady‐state level of HA did not change after intraperitoneal administration of ethanol (0.5–5 g/kg), whereas the level of tele‐methylhistamine (t‐MH), a predominant metabolite of brain HA, increased when 3 and 5 g/kg of ethanol was given. Pargyline hydrochloride (80 mg/kg, i.p.) increased the level of t‐MH by 72.2% 90 min after the treatment. Ethanol at any dose given did not significantly affect the t‐MH level in the pargyline‐pretreated mice. Decrease in the t‐MH level induced by metoprine (10 mg/kg, i.p.), an inhibitor of HA‐N‐methyltransferase, was suppressed by ethanol (5 g/kg), thereby suggesting inhibition of the elimination of brain t‐MH. Ethanol (5 g/kg) significantly delayed the depletion of HA induced by (S)‐α‐fluoromethylhistidine (50 mg/kg, i.v.), a specific inhibitor of histidine decarboxylase. Therefore, a large dose of ethanol apparently decreases HA turnover in the mouse hypothalamus.
KW - Ethanol
KW - Histamine
KW - Histamine turnover
KW - Hypothalamus
KW - tele‐Methylhistamine
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U2 - 10.1111/j.1471-4159.1985.tb10547.x
DO - 10.1111/j.1471-4159.1985.tb10547.x
M3 - Article
C2 - 4056796
AN - SCOPUS:0022395549
VL - 45
SP - 1880
EP - 1885
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
SN - 0022-3042
IS - 6
ER -