Changes in Histamine Metabolism in the Mouse Hypothalamus Induced by Acute Administration of Ethanol

Yoshinori Itoh, Masahiro Nishibori, Ryozo Oishi, Kiyomi Saeki

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Abstract: The effect of acute ethanol administration on histamine (HA) dynamics was examined in the mouse hypothalamus. The steady‐state level of HA did not change after intraperitoneal administration of ethanol (0.5–5 g/kg), whereas the level of tele‐methylhistamine (t‐MH), a predominant metabolite of brain HA, increased when 3 and 5 g/kg of ethanol was given. Pargyline hydrochloride (80 mg/kg, i.p.) increased the level of t‐MH by 72.2% 90 min after the treatment. Ethanol at any dose given did not significantly affect the t‐MH level in the pargyline‐pretreated mice. Decrease in the t‐MH level induced by metoprine (10 mg/kg, i.p.), an inhibitor of HA‐N‐methyltransferase, was suppressed by ethanol (5 g/kg), thereby suggesting inhibition of the elimination of brain t‐MH. Ethanol (5 g/kg) significantly delayed the depletion of HA induced by (S)‐α‐fluoromethylhistidine (50 mg/kg, i.v.), a specific inhibitor of histidine decarboxylase. Therefore, a large dose of ethanol apparently decreases HA turnover in the mouse hypothalamus.

Original languageEnglish
Pages (from-to)1880-1885
Number of pages6
JournalJournal of Neurochemistry
Volume45
Issue number6
DOIs
Publication statusPublished - Dec 1985

Keywords

  • Ethanol
  • Histamine
  • Histamine turnover
  • Hypothalamus
  • tele‐Methylhistamine

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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