Changes in glomerular extracellular matrices components in diabetic nephropathy

Shuji Ikeda, Hirofumi Makino, Toshinori Haramoto, Kenichi Shikata, Isao Kumagai, Zensuke Ota

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

The changes in glomerular extracellular matrices components in diabetic nephropathy were investigated. Indirect immunofluorescence staining, using polyclonal antibodies to heparan sulfate proteoglycan (HS-PG), laminin, type IV collagen, and fibronectin was carried out on renal specimens obtained by needle biopsy. Immunofluorescence intensity and distribution were observed. HS-PG and laminin decreased in the capillary walls; on the other hand, type IV collagen and fibronectin tended to increase in the mesangial area. HS-PG and laminin decreased in inverse proportion to sclerosis grades and proteinuria. These changes seemed to play an important role in progression of diabetic glomerulosclerosis.

Original languageEnglish
Pages (from-to)186-188
Number of pages3
JournalJournal of Diabetic Complications
Volume5
Issue number2-3
DOIs
Publication statusPublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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