Changes in cerebral oxygen saturation and haemoglobin concentration during paediatric cardiac surgery

T. Suemori, S. B. Horton, S. Bottrell, J. J. Skowno, A. Davidson

Research output: Contribution to journalArticle

Abstract

Although near-infrared spectroscopy (NIRS) enables bedside assessment of cerebral oxygenation, it provides little information on the cause of deoxygenation. The authors aimed to investigate the changes in cerebral oxygenation and haemoglobin concentration and their associations during paediatric cardiac surgery in order to elucidate the physiology underlying cerebral deoxygenation. An observational retrospective study on 399 patients who underwent paediatric cardiac surgery was conducted. With use of NIRS, cerebral oxygen saturation as expressed by tissue oxygen index (TOI) before and after surgery, concentration changes in oxygenated haemoglobin (δ[HbO2]) and deoxygenated haemoglobin (δ[HHb]) after surgery were studied as were the associations between these values and clinical variables. TOI decreased after surgery (preoperative versus postoperative value, 66.0% [56.9, 71.3] versus 63.2% [54.3, 69.4], median [25th, 75th percentile], P <0.001) and the decrease was greater in higher category groups in the Risk Adjusted Classification for Congenital Heart Surgery (RACHS-1). [HHb] increased from its baseline (+1.74 μmol/l [-1.57, +5.84], P <0.001) and the increase was greater in higher risk category groups. On the contrary, there was no evidence for a change in [HbO2] (+0.45 μmol/l [-4.76, +5.30], P=0.42). Cerebral oxygen saturation decreased after paediatric cardiac surgery and the decrease was greater in patients of higher risk groups. The increase in [HHb] was considered to play a predominant role in the cerebral deoxygenation noted, in particular in higher RACHS-1 category groups.

Original languageEnglish
Pages (from-to)220-227
Number of pages8
JournalAnaesthesia and Intensive Care
Volume45
Issue number2
Publication statusPublished - Mar 1 2017

Fingerprint

Thoracic Surgery
Hemoglobins
Pediatrics
Oxygen
Near-Infrared Spectroscopy
Observational Studies
Retrospective Studies

Keywords

  • Cerebral ischaemia
  • Congenital heart defects
  • Deoxyhaemoglobin
  • Near-infrared spectroscopy
  • Oxyhaemoglobin
  • Perioperative care

ASJC Scopus subject areas

  • Medicine(all)
  • Critical Care and Intensive Care Medicine
  • Anesthesiology and Pain Medicine

Cite this

Suemori, T., Horton, S. B., Bottrell, S., Skowno, J. J., & Davidson, A. (2017). Changes in cerebral oxygen saturation and haemoglobin concentration during paediatric cardiac surgery. Anaesthesia and Intensive Care, 45(2), 220-227.

Changes in cerebral oxygen saturation and haemoglobin concentration during paediatric cardiac surgery. / Suemori, T.; Horton, S. B.; Bottrell, S.; Skowno, J. J.; Davidson, A.

In: Anaesthesia and Intensive Care, Vol. 45, No. 2, 01.03.2017, p. 220-227.

Research output: Contribution to journalArticle

Suemori, T, Horton, SB, Bottrell, S, Skowno, JJ & Davidson, A 2017, 'Changes in cerebral oxygen saturation and haemoglobin concentration during paediatric cardiac surgery', Anaesthesia and Intensive Care, vol. 45, no. 2, pp. 220-227.
Suemori, T. ; Horton, S. B. ; Bottrell, S. ; Skowno, J. J. ; Davidson, A. / Changes in cerebral oxygen saturation and haemoglobin concentration during paediatric cardiac surgery. In: Anaesthesia and Intensive Care. 2017 ; Vol. 45, No. 2. pp. 220-227.
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