Changes in CD4+CD8-/CD4-CD8+ ratio and humoral immune functions in vitamin B12-deficient rats

U. Funada; M. Wada; T. Kawata; K. Mori; H. Tamai; T. Kawanishi; A. Kunou; N. Tanaka; T. Tadokoro; A. Maekawa

doi:10.1024/0300-9831.70.4.167

Changes in CD4⁺CD8^-/CD4^-CD8⁺ ratio and humoral immune functions in vitamin B₁₂-deficient rats

U. Funada, M. Wada, T. Kawata, K. Mori, H. Tamai, T. Kawanishi, A. Kunou, N. Tanaka, T. Tadokoro, A. Maekawa

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

To clarify the role of vitamin B₁₂ in the function of cell-mediated and humoral immune functions, the splenocytes expression of CD4, CD8 and serum C3, IgM, IgG concentrations were examined in vitamin B₁₂-deficient rats, and the effect of the administration of methylcobalamin was also studied. The CD4⁺CD8^-/CD4^-CD8⁺ ratio in splenocytes was significantly higher in vitamin B₁₂-deficient rats than in control rats (p < 0.05). The value in the 48 hours after methylcobalamin administration group, was within the normal range (p < 0.05). From these results, the elevation of the CD4⁺CD8^-/CD4^-CD8⁺ ratio by vitamin B₁₂-deficiency was confirmed in rats. The serum C3, IgM and IgG concentrations were lower in the vitamin B₁₂-deficient group than in the control group. These findings suggest that vitamin B₁₂ plays a role in maintaining the immune function in rats.

Original language	English
Pages (from-to)	167-171
Number of pages	5
Journal	International Journal for Vitamin and Nutrition Research
Volume	70
Issue number	4
DOIs	https://doi.org/10.1024/0300-9831.70.4.167
Publication status	Published - Jan 1 2000
Externally published	Yes

Keywords

CD4
CD8
Serum C3
Serum IgG
Serum IgM
Vitamin B-deficiency

ASJC Scopus subject areas

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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Changes in CD4⁺CD8^-/CD4^-CD8⁺ ratio and humoral immune functions in vitamin B₁₂-deficient rats. / Funada, U.; Wada, M.; Kawata, T.; Mori, K.; Tamai, H.; Kawanishi, T.; Kunou, A.; Tanaka, N.; Tadokoro, T.; Maekawa, A.

In: International Journal for Vitamin and Nutrition Research, Vol. 70, No. 4, 01.01.2000, p. 167-171.

Research output: Contribution to journal › Article › peer-review

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abstract = "To clarify the role of vitamin B12 in the function of cell-mediated and humoral immune functions, the splenocytes expression of CD4, CD8 and serum C3, IgM, IgG concentrations were examined in vitamin B12-deficient rats, and the effect of the administration of methylcobalamin was also studied. The CD4+CD8-/CD4-CD8+ ratio in splenocytes was significantly higher in vitamin B12-deficient rats than in control rats (p < 0.05). The value in the 48 hours after methylcobalamin administration group, was within the normal range (p < 0.05). From these results, the elevation of the CD4+CD8-/CD4-CD8+ ratio by vitamin B12-deficiency was confirmed in rats. The serum C3, IgM and IgG concentrations were lower in the vitamin B12-deficient group than in the control group. These findings suggest that vitamin B12 plays a role in maintaining the immune function in rats.",

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AU - Tamai, H.

AU - Kawanishi, T.

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