Changes in CD4+CD8-/CD4-CD8+ ratio and humoral immune functions in vitamin B12-deficient rats

U. Funada, M. Wada, Tetsunori Kawata, K. Mori, H. Tamai, T. Kawanishi, A. Kunou, N. Tanaka, T. Tadokoro, A. Maekawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

To clarify the role of vitamin B12 in the function of cell-mediated and humoral immune functions, the splenocytes expression of CD4, CD8 and serum C3, IgM, IgG concentrations were examined in vitamin B12-deficient rats, and the effect of the administration of methylcobalamin was also studied. The CD4+CD8-/CD4-CD8+ ratio in splenocytes was significantly higher in vitamin B12-deficient rats than in control rats (p <0.05). The value in the 48 hours after methylcobalamin administration group, was within the normal range (p <0.05). From these results, the elevation of the CD4+CD8-/CD4-CD8+ ratio by vitamin B12-deficiency was confirmed in rats. The serum C3, IgM and IgG concentrations were lower in the vitamin B12-deficient group than in the control group. These findings suggest that vitamin B12 plays a role in maintaining the immune function in rats.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalInternational Journal for Vitamin and Nutrition Research
Volume70
Issue number4
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

CD4-CD8 Ratio
vitamin B12
Vitamin B 12
rats
Immunoglobulin M
splenocytes
Immunoglobulin G
Vitamin B 12 Deficiency
Serum
Reference Values
Control Groups

Keywords

  • CD4
  • CD8
  • Serum C3
  • Serum IgG
  • Serum IgM
  • Vitamin B-deficiency

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Changes in CD4+CD8-/CD4-CD8+ ratio and humoral immune functions in vitamin B12-deficient rats. / Funada, U.; Wada, M.; Kawata, Tetsunori; Mori, K.; Tamai, H.; Kawanishi, T.; Kunou, A.; Tanaka, N.; Tadokoro, T.; Maekawa, A.

In: International Journal for Vitamin and Nutrition Research, Vol. 70, No. 4, 2000, p. 167-171.

Research output: Contribution to journalArticle

Funada, U, Wada, M, Kawata, T, Mori, K, Tamai, H, Kawanishi, T, Kunou, A, Tanaka, N, Tadokoro, T & Maekawa, A 2000, 'Changes in CD4+CD8-/CD4-CD8+ ratio and humoral immune functions in vitamin B12-deficient rats', International Journal for Vitamin and Nutrition Research, vol. 70, no. 4, pp. 167-171.
Funada, U. ; Wada, M. ; Kawata, Tetsunori ; Mori, K. ; Tamai, H. ; Kawanishi, T. ; Kunou, A. ; Tanaka, N. ; Tadokoro, T. ; Maekawa, A. / Changes in CD4+CD8-/CD4-CD8+ ratio and humoral immune functions in vitamin B12-deficient rats. In: International Journal for Vitamin and Nutrition Research. 2000 ; Vol. 70, No. 4. pp. 167-171.
@article{98ec7196786a414dbf27681404294441,
title = "Changes in CD4+CD8-/CD4-CD8+ ratio and humoral immune functions in vitamin B12-deficient rats",
abstract = "To clarify the role of vitamin B12 in the function of cell-mediated and humoral immune functions, the splenocytes expression of CD4, CD8 and serum C3, IgM, IgG concentrations were examined in vitamin B12-deficient rats, and the effect of the administration of methylcobalamin was also studied. The CD4+CD8-/CD4-CD8+ ratio in splenocytes was significantly higher in vitamin B12-deficient rats than in control rats (p <0.05). The value in the 48 hours after methylcobalamin administration group, was within the normal range (p <0.05). From these results, the elevation of the CD4+CD8-/CD4-CD8+ ratio by vitamin B12-deficiency was confirmed in rats. The serum C3, IgM and IgG concentrations were lower in the vitamin B12-deficient group than in the control group. These findings suggest that vitamin B12 plays a role in maintaining the immune function in rats.",
keywords = "CD4, CD8, Serum C3, Serum IgG, Serum IgM, Vitamin B-deficiency",
author = "U. Funada and M. Wada and Tetsunori Kawata and K. Mori and H. Tamai and T. Kawanishi and A. Kunou and N. Tanaka and T. Tadokoro and A. Maekawa",
year = "2000",
language = "English",
volume = "70",
pages = "167--171",
journal = "Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie",
issn = "0300-9831",
publisher = "Verlag Hans Huber",
number = "4",

}

TY - JOUR

T1 - Changes in CD4+CD8-/CD4-CD8+ ratio and humoral immune functions in vitamin B12-deficient rats

AU - Funada, U.

AU - Wada, M.

AU - Kawata, Tetsunori

AU - Mori, K.

AU - Tamai, H.

AU - Kawanishi, T.

AU - Kunou, A.

AU - Tanaka, N.

AU - Tadokoro, T.

AU - Maekawa, A.

PY - 2000

Y1 - 2000

N2 - To clarify the role of vitamin B12 in the function of cell-mediated and humoral immune functions, the splenocytes expression of CD4, CD8 and serum C3, IgM, IgG concentrations were examined in vitamin B12-deficient rats, and the effect of the administration of methylcobalamin was also studied. The CD4+CD8-/CD4-CD8+ ratio in splenocytes was significantly higher in vitamin B12-deficient rats than in control rats (p <0.05). The value in the 48 hours after methylcobalamin administration group, was within the normal range (p <0.05). From these results, the elevation of the CD4+CD8-/CD4-CD8+ ratio by vitamin B12-deficiency was confirmed in rats. The serum C3, IgM and IgG concentrations were lower in the vitamin B12-deficient group than in the control group. These findings suggest that vitamin B12 plays a role in maintaining the immune function in rats.

AB - To clarify the role of vitamin B12 in the function of cell-mediated and humoral immune functions, the splenocytes expression of CD4, CD8 and serum C3, IgM, IgG concentrations were examined in vitamin B12-deficient rats, and the effect of the administration of methylcobalamin was also studied. The CD4+CD8-/CD4-CD8+ ratio in splenocytes was significantly higher in vitamin B12-deficient rats than in control rats (p <0.05). The value in the 48 hours after methylcobalamin administration group, was within the normal range (p <0.05). From these results, the elevation of the CD4+CD8-/CD4-CD8+ ratio by vitamin B12-deficiency was confirmed in rats. The serum C3, IgM and IgG concentrations were lower in the vitamin B12-deficient group than in the control group. These findings suggest that vitamin B12 plays a role in maintaining the immune function in rats.

KW - CD4

KW - CD8

KW - Serum C3

KW - Serum IgG

KW - Serum IgM

KW - Vitamin B-deficiency

UR - http://www.scopus.com/inward/record.url?scp=0033869003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033869003&partnerID=8YFLogxK

M3 - Article

C2 - 10989765

AN - SCOPUS:0033869003

VL - 70

SP - 167

EP - 171

JO - Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie

JF - Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie

SN - 0300-9831

IS - 4

ER -