Changes in CD4+CD8-/CD4-CD8+ ratio and humoral immune functions in vitamin B12-deficient rats

U. Funada, M. Wada, Tetsunori Kawata, K. Mori, H. Tamai, T. Kawanishi, A. Kunou, N. Tanaka, T. Tadokoro, A. Maekawa

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Abstract

To clarify the role of vitamin B12 in the function of cell-mediated and humoral immune functions, the splenocytes expression of CD4, CD8 and serum C3, IgM, IgG concentrations were examined in vitamin B12-deficient rats, and the effect of the administration of methylcobalamin was also studied. The CD4+CD8-/CD4-CD8+ ratio in splenocytes was significantly higher in vitamin B12-deficient rats than in control rats (p <0.05). The value in the 48 hours after methylcobalamin administration group, was within the normal range (p <0.05). From these results, the elevation of the CD4+CD8-/CD4-CD8+ ratio by vitamin B12-deficiency was confirmed in rats. The serum C3, IgM and IgG concentrations were lower in the vitamin B12-deficient group than in the control group. These findings suggest that vitamin B12 plays a role in maintaining the immune function in rats.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalInternational Journal for Vitamin and Nutrition Research
Volume70
Issue number4
Publication statusPublished - 2000
Externally publishedYes

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Keywords

  • CD4
  • CD8
  • Serum C3
  • Serum IgG
  • Serum IgM
  • Vitamin B-deficiency

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Funada, U., Wada, M., Kawata, T., Mori, K., Tamai, H., Kawanishi, T., Kunou, A., Tanaka, N., Tadokoro, T., & Maekawa, A. (2000). Changes in CD4+CD8-/CD4-CD8+ ratio and humoral immune functions in vitamin B12-deficient rats. International Journal for Vitamin and Nutrition Research, 70(4), 167-171.