CGRP in peripherally axotomized mesencephalic trigeminal neurones of the rat

Akihiro Yoshida, Hiroyuki Ichikawa, Tomosada Sugimoto

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Immunoreactivities for substance P (SP-ir) and calcitonin gene-related peptide (CGRP-ir) were examined in neurones in the mesencephalic trigeminal tract nucleus of nerve-injured rats. One week following unilateral transection of the trigeminal root, the masseteric nerve (MN) or the inferior alveolar nerve (IAN), CGRP-ir but not SP-ir was detected in these neurones bilaterally with ipsilateral dominance. Most of the CGRP-ir (immunoreactive) neurones were retrogradely labelled when fluorogold (FG) had been applied to the proximal stump of the MN or the IAN. Sham surgery including insult to the masseter muscle induced CGRP-ir while skin incision did not.

Original languageEnglish
Pages (from-to)837-840
Number of pages4
JournalNeuroReport
Volume6
Issue number6
DOIs
Publication statusPublished - Apr 1995

Keywords

  • Calcitonin gene-related peptide
  • Inferior alveolar nerve
  • Masseteric nerve
  • Mesencephalic trigeminal tract nucleus
  • Peripheral axotomy
  • Trigeminal nerve root

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'CGRP in peripherally axotomized mesencephalic trigeminal neurones of the rat'. Together they form a unique fingerprint.

  • Cite this