Ceruletide suppresses rotational behavior in lesioned rats via CCKA receptors

Mutsuo Fujisawa; Osamu Miyamoto; Toshifumi Itano; Masaaki Tokuda; Hideki Matsui; Seigo Nagao; Tetsuro Negi; Osamu Hatase

doi:10.1016/0014-2999(93)90516-K

Ceruletide suppresses rotational behavior in lesioned rats via CCK_A receptors

Mutsuo Fujisawa, Osamu Miyamoto, Toshifumi Itano, Masaaki Tokuda, Hideki Matsui, Seigo Nagao, Tetsuro Negi, Osamu Hatase

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The effects and pharmacological mechanisms underlying the inhibiting effect of ceruletide, a cholecystokinin (CCK)-related peptide, on apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats were investigated. For this purpose, selective CCK_A and CCK_B receptor antagonists were used. Ceruletide (50-400 μg/kg, s.c.) dose dependently suppressed apomorphine-induced rotational behavior. The antiapomorphine effect of ceruletide was reversed by the selective CCK_A receptor antagonist, devazepide, but not by the selective CCK_B receptor antagonist, L-365,260. This suggests that the suppression ceruletide exerts on hyperactive nigrostriatal dopamine neurons is mediated by CCK_A receptors.

Original language	English
Pages (from-to)	127-130
Number of pages	4
Journal	European Journal of Pharmacology
Volume	238
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(93)90516-K
Publication status	Published - Jul 6 1993

Keywords

CCK (cholecystokinin)
CCK receptors
CCK receptors
Ceruletide
Parkinson's disease
Rotational behaviour

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(93)90516-K

Cite this

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title = "Ceruletide suppresses rotational behavior in lesioned rats via CCKA receptors",

abstract = "The effects and pharmacological mechanisms underlying the inhibiting effect of ceruletide, a cholecystokinin (CCK)-related peptide, on apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats were investigated. For this purpose, selective CCKA and CCKB receptor antagonists were used. Ceruletide (50-400 μg/kg, s.c.) dose dependently suppressed apomorphine-induced rotational behavior. The antiapomorphine effect of ceruletide was reversed by the selective CCKA receptor antagonist, devazepide, but not by the selective CCKB receptor antagonist, L-365,260. This suggests that the suppression ceruletide exerts on hyperactive nigrostriatal dopamine neurons is mediated by CCKA receptors.",

keywords = "CCK (cholecystokinin), CCK receptors, CCK receptors, Ceruletide, Parkinson's disease, Rotational behaviour",

author = "Mutsuo Fujisawa and Osamu Miyamoto and Toshifumi Itano and Masaaki Tokuda and Hideki Matsui and Seigo Nagao and Tetsuro Negi and Osamu Hatase",

year = "1993",

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T1 - Ceruletide suppresses rotational behavior in lesioned rats via CCKA receptors

AU - Fujisawa, Mutsuo

AU - Miyamoto, Osamu

AU - Itano, Toshifumi

AU - Tokuda, Masaaki

AU - Matsui, Hideki

AU - Nagao, Seigo

AU - Negi, Tetsuro

AU - Hatase, Osamu

PY - 1993/7/6

Y1 - 1993/7/6

N2 - The effects and pharmacological mechanisms underlying the inhibiting effect of ceruletide, a cholecystokinin (CCK)-related peptide, on apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats were investigated. For this purpose, selective CCKA and CCKB receptor antagonists were used. Ceruletide (50-400 μg/kg, s.c.) dose dependently suppressed apomorphine-induced rotational behavior. The antiapomorphine effect of ceruletide was reversed by the selective CCKA receptor antagonist, devazepide, but not by the selective CCKB receptor antagonist, L-365,260. This suggests that the suppression ceruletide exerts on hyperactive nigrostriatal dopamine neurons is mediated by CCKA receptors.

AB - The effects and pharmacological mechanisms underlying the inhibiting effect of ceruletide, a cholecystokinin (CCK)-related peptide, on apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats were investigated. For this purpose, selective CCKA and CCKB receptor antagonists were used. Ceruletide (50-400 μg/kg, s.c.) dose dependently suppressed apomorphine-induced rotational behavior. The antiapomorphine effect of ceruletide was reversed by the selective CCKA receptor antagonist, devazepide, but not by the selective CCKB receptor antagonist, L-365,260. This suggests that the suppression ceruletide exerts on hyperactive nigrostriatal dopamine neurons is mediated by CCKA receptors.

KW - CCK (cholecystokinin)

KW - CCK receptors

KW - Ceruletide

KW - Parkinson's disease

KW - Rotational behaviour

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