Ceruletide suppresses rotational behavior in lesioned rats via CCKA receptors

Mutsuo Fujisawa, Osamu Miyamoto, Toshifumi Itano, Masaaki Tokuda, Hideki Matsui, Seigo Nagao, Tetsuro Negi, Osamu Hatase

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effects and pharmacological mechanisms underlying the inhibiting effect of ceruletide, a cholecystokinin (CCK)-related peptide, on apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats were investigated. For this purpose, selective CCKA and CCKB receptor antagonists were used. Ceruletide (50-400 μg/kg, s.c.) dose dependently suppressed apomorphine-induced rotational behavior. The antiapomorphine effect of ceruletide was reversed by the selective CCKA receptor antagonist, devazepide, but not by the selective CCKB receptor antagonist, L-365,260. This suggests that the suppression ceruletide exerts on hyperactive nigrostriatal dopamine neurons is mediated by CCKA receptors.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalEuropean Journal of Pharmacology
Volume238
Issue number1
DOIs
Publication statusPublished - Jul 6 1993

Keywords

  • CCK (cholecystokinin)
  • CCK receptors
  • CCK receptors
  • Ceruletide
  • Parkinson's disease
  • Rotational behaviour

ASJC Scopus subject areas

  • Pharmacology

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    Fujisawa, M., Miyamoto, O., Itano, T., Tokuda, M., Matsui, H., Nagao, S., Negi, T., & Hatase, O. (1993). Ceruletide suppresses rotational behavior in lesioned rats via CCKA receptors. European Journal of Pharmacology, 238(1), 127-130. https://doi.org/10.1016/0014-2999(93)90516-K