Ceruletide suppresses rotational behavior in lesioned rats via CCKA receptors

Mutsuo Fujisawa, Osamu Miyamoto, Toshifumi Itano, Masaaki Tokuda, Hideki Matsui, Seigo Nagao, Tetsuro Negi, Osamu Hatase

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effects and pharmacological mechanisms underlying the inhibiting effect of ceruletide, a cholecystokinin (CCK)-related peptide, on apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats were investigated. For this purpose, selective CCKA and CCKB receptor antagonists were used. Ceruletide (50-400 μg/kg, s.c.) dose dependently suppressed apomorphine-induced rotational behavior. The antiapomorphine effect of ceruletide was reversed by the selective CCKA receptor antagonist, devazepide, but not by the selective CCKB receptor antagonist, L-365,260. This suggests that the suppression ceruletide exerts on hyperactive nigrostriatal dopamine neurons is mediated by CCKA receptors.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalEuropean Journal of Pharmacology
Volume238
Issue number1
DOIs
Publication statusPublished - Jul 6 1993
Externally publishedYes

Fingerprint

Ceruletide
Apomorphine
Devazepide
Oxidopamine
Dopaminergic Neurons
Cholecystokinin
Pharmacology
Peptides

Keywords

  • CCK (cholecystokinin)
  • CCK receptors
  • CCK receptors
  • Ceruletide
  • Parkinson's disease
  • Rotational behaviour

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Fujisawa, M., Miyamoto, O., Itano, T., Tokuda, M., Matsui, H., Nagao, S., ... Hatase, O. (1993). Ceruletide suppresses rotational behavior in lesioned rats via CCKA receptors. European Journal of Pharmacology, 238(1), 127-130. https://doi.org/10.1016/0014-2999(93)90516-K

Ceruletide suppresses rotational behavior in lesioned rats via CCKA receptors. / Fujisawa, Mutsuo; Miyamoto, Osamu; Itano, Toshifumi; Tokuda, Masaaki; Matsui, Hideki; Nagao, Seigo; Negi, Tetsuro; Hatase, Osamu.

In: European Journal of Pharmacology, Vol. 238, No. 1, 06.07.1993, p. 127-130.

Research output: Contribution to journalArticle

Fujisawa, M, Miyamoto, O, Itano, T, Tokuda, M, Matsui, H, Nagao, S, Negi, T & Hatase, O 1993, 'Ceruletide suppresses rotational behavior in lesioned rats via CCKA receptors', European Journal of Pharmacology, vol. 238, no. 1, pp. 127-130. https://doi.org/10.1016/0014-2999(93)90516-K
Fujisawa, Mutsuo ; Miyamoto, Osamu ; Itano, Toshifumi ; Tokuda, Masaaki ; Matsui, Hideki ; Nagao, Seigo ; Negi, Tetsuro ; Hatase, Osamu. / Ceruletide suppresses rotational behavior in lesioned rats via CCKA receptors. In: European Journal of Pharmacology. 1993 ; Vol. 238, No. 1. pp. 127-130.
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