Cerebrospinal fluid tau in dementia disorders: A large scale multicenter study by a Japanese study group

Mikio Shoji, Etsuro Matsubara, Tetsuro Murakami, Yasuhiro Manabe, Koji Abe, Mitsuyasu Kanai, Masaki Ikeda, Yasushi Tomidokoro, Masami Shizuka, Mitsunori Watanabe, Masakuni Amari, Koji Ishiguro, Takeshi Kawarabayashi, Yasuo Harigaya, Koichi Okamoto, Tsuyosi Nishimura, Yu Nakamura, Masatoshi Takeda, Katsuya Urakami, Yoshiki AdachiKenji Nakashima, Hiroyuki Arai, Hidetada Sasaki, Kazutomi Kanemaru, Hiroshi Yamanouchi, Yasuji Yoshida, Kunihiro Ichise, Kuniaki Tanaka, Makoto Hamamoto, Hideki Yamamoto, Takeyuki Matsubayashi, Hiroshi Yoshida, Hiromasa Toji, Shigenobu Nakamura, Shunsaku Hirai

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

A large scale multicenter study of cerebrospinal fluid (CSF) tau levels was conducted to determine the cut-off value, sensitivity and specificity for clinical usage as a biomarker of Alzheimer's disease (AD). Its use for early and differential diagnosis and the factors that increase CSF tau levels were also examined. CSF samples from a total of 1,031 subjects including 366 patients with AD, 168 patients with non-Alzheimer type dementia (NA), 316 patients with non-dementia neurological diseases (ND) and 181 normal controls (NC) were measured using ELISA for tau. The cut-off value of tau, 375 pg/ml, showed 59.1% sensitivity and 89.5% specificity for diagnosis of AD compared with the other groups. The tau levels were increased from the early to late stages of AD. Elevation of CSF tau in the non-tauopathy and tauopathy dementia groups, chronic and acute damage to the cerebrum, and meningeal disturbance were other factors that required attention for clinical practice. Measurement of CSF tau was useful as a biomarker for early and differential diagnosis of AD.

Original languageEnglish
Pages (from-to)363-370
Number of pages8
JournalNeurobiology of Aging
Volume23
Issue number3
DOIs
Publication statusPublished - 2002

Keywords

  • Alzheimer's disease
  • Cerebrospinal fluid
  • Diagnosis
  • Large scale multicenter study
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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    Shoji, M., Matsubara, E., Murakami, T., Manabe, Y., Abe, K., Kanai, M., Ikeda, M., Tomidokoro, Y., Shizuka, M., Watanabe, M., Amari, M., Ishiguro, K., Kawarabayashi, T., Harigaya, Y., Okamoto, K., Nishimura, T., Nakamura, Y., Takeda, M., Urakami, K., ... Hirai, S. (2002). Cerebrospinal fluid tau in dementia disorders: A large scale multicenter study by a Japanese study group. Neurobiology of Aging, 23(3), 363-370. https://doi.org/10.1016/S0197-4580(01)00309-8