Cerebrospinal blood flow and its regulation

Toru Yamashita; Kazunori Miyazaki; Koji Abe

doi:10.1007/978-4-431-54490-6_2

Cerebrospinal blood flow and its regulation

Toru Yamashita, Kazunori Miyazaki, Koji Abe

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The human brain utilizes large amounts of O₂, which means that the rate of blood flow has to be maintained at a consistently high level. This is made possible by "cerebral autoregulation," the process by which the cerebral and spinal blood vessels keep cerebral blood flow constant, even under change in systemic blood pressure. In addition, cerebral and spinal blood flow and its regulation appear to be closely related not only to vascular disease phenotype but also the pathophysiology of various neurodegenerative disorders, including Alzheimer's disease and amyotrophic lateral sclerosis. In this review, we briefly highlight cerebral and spinal blood flow and its autoregulation and show its relationship to neurological diseases.

Original language	English
Title of host publication	Neuroanesthesia and Cerebrospinal Protection
Publisher	Springer Japan
Pages	25-29
Number of pages	5
ISBN (Electronic)	9784431544906
ISBN (Print)	9784431544890
DOIs	https://doi.org/10.1007/978-4-431-54490-6_2
Publication status	Published - Aug 7 2015

Keywords

Amyotrophic lateral sclerosis (ALS)
Cerebral autoregulation
Cerebral blood flow
Flow-metabolism coupling

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-4-431-54490-6_2

Cite this

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AU - Abe, Koji

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AB - The human brain utilizes large amounts of O2, which means that the rate of blood flow has to be maintained at a consistently high level. This is made possible by "cerebral autoregulation," the process by which the cerebral and spinal blood vessels keep cerebral blood flow constant, even under change in systemic blood pressure. In addition, cerebral and spinal blood flow and its regulation appear to be closely related not only to vascular disease phenotype but also the pathophysiology of various neurodegenerative disorders, including Alzheimer's disease and amyotrophic lateral sclerosis. In this review, we briefly highlight cerebral and spinal blood flow and its autoregulation and show its relationship to neurological diseases.

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Cerebrospinal blood flow and its regulation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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