Cerebrospinal blood flow and its regulation

Toru Yamashita, Kazunori Miyazaki, Koji Abe

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The human brain utilizes large amounts of O2, which means that the rate of blood flow has to be maintained at a consistently high level. This is made possible by "cerebral autoregulation," the process by which the cerebral and spinal blood vessels keep cerebral blood flow constant, even under change in systemic blood pressure. In addition, cerebral and spinal blood flow and its regulation appear to be closely related not only to vascular disease phenotype but also the pathophysiology of various neurodegenerative disorders, including Alzheimer's disease and amyotrophic lateral sclerosis. In this review, we briefly highlight cerebral and spinal blood flow and its autoregulation and show its relationship to neurological diseases.

Original languageEnglish
Title of host publicationNeuroanesthesia and Cerebrospinal Protection
PublisherSpringer Japan
Pages25-29
Number of pages5
ISBN (Electronic)9784431544906
ISBN (Print)9784431544890
DOIs
Publication statusPublished - Aug 7 2015

Keywords

  • Amyotrophic lateral sclerosis (ALS)
  • Cerebral autoregulation
  • Cerebral blood flow
  • Flow-metabolism coupling

ASJC Scopus subject areas

  • Medicine(all)

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