Cerebral oxygen saturation and tissue hemoglobin concentration as predictive markers of early postoperative outcomes after pediatric cardiac surgery

Tomohiko Suemori, Justin Skowno, Steve Horton, Stephen Bottrell, Warwick Butt, Andrew J. Davidson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Summary Background Near-infrared spectroscopy (NIRS) provides an assessment of cerebral oxygenation and tissue hemoglobin concentration. Aim The aim of this study was to investigate whether the cerebral oxygenation and hemoglobin concentration measured with NIRS could predict outcomes after pediatric cardiac surgery. Method We conducted a retrospective observational study in 399 patients who underwent pediatric cardiac surgery. Associations were determined between postoperative outcome and preoperative and postoperative cerebral tissue oxygenation index (TOI), postoperative normalized tissue hemoglobin index (nTHI), concentration changes in oxygenated hemoglobin (Δ[HbO2]) and deoxygenated hemoglobin (Δ[HHb]). Results Thirty-nine children had major postoperative morbidity and 12 died. Using Spearman's correlation analysis, postoperative lower TOI and higher Δ[HHb] were associated with longer stays in the Intensive Care Unit (ICU) (r = -0.48, P <0.001, r = 0.31, P <0.001, respectively) and longer duration of intubation (r = -0.48, P <0.001, r = 0.31, P <0.001, respectively) and higher probability of death determined by the Risk Adjusted Classification for Congenital Heart Surgery (RACHS-1) (r = -0.39, P <0.001, r = 0.23, P <0.001, respectively). In multivariate regression analysis, postoperative TOI was independently associated with major morbidity and mortality and Δ[HHb] was independently associated with major morbidity. In receiver operating characteristic analysis, postoperative TOI and Δ[HHb] predicted major morbidity (Area under the curve [AUC] = 0.72, 0.68, respectively) and mortality (AUC = 0.81, 0.69, respectively). Conclusion Lower TOI or higher [HHb] at the end of surgery and higher RACHS-1 category predicted worse outcomes.

Original languageEnglish
Pages (from-to)182-189
Number of pages8
JournalPaediatric Anaesthesia
Volume26
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Thoracic Surgery
Hemoglobins
Pediatrics
Oxygen
Morbidity
Near-Infrared Spectroscopy
Area Under Curve
Mortality
Intubation
ROC Curve
Observational Studies
Intensive Care Units
Multivariate Analysis
Retrospective Studies
Regression Analysis

Keywords

  • cerebral ischemia
  • congenital heart defects
  • deoxyhemoglobin
  • near-infrared spectroscopy
  • oxyhemoglobin
  • prognosis

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Cerebral oxygen saturation and tissue hemoglobin concentration as predictive markers of early postoperative outcomes after pediatric cardiac surgery. / Suemori, Tomohiko; Skowno, Justin; Horton, Steve; Bottrell, Stephen; Butt, Warwick; Davidson, Andrew J.

In: Paediatric Anaesthesia, Vol. 26, No. 2, 01.02.2016, p. 182-189.

Research output: Contribution to journalArticle

Suemori, Tomohiko ; Skowno, Justin ; Horton, Steve ; Bottrell, Stephen ; Butt, Warwick ; Davidson, Andrew J. / Cerebral oxygen saturation and tissue hemoglobin concentration as predictive markers of early postoperative outcomes after pediatric cardiac surgery. In: Paediatric Anaesthesia. 2016 ; Vol. 26, No. 2. pp. 182-189.
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