Ceratinadins A-C, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp.

Yuji Kon; Takaaki Kubota; Azusa Shibazaki; Tohru Gonoi; Jun'Ichi Kobayashi

doi:10.1016/j.bmcl.2010.06.015

Ceratinadins A-C, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp.

Yuji Kon, Takaaki Kubota, Azusa Shibazaki, Tohru Gonoi, Jun'Ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Three new bromotyrosine alkaloids, ceratinadins A-C (1-3), were isolated from an Okinawan marine sponge Pseudoceratina sp. and the structures of 1-3 were elucidated on the basis of spectroscopic data. Ceratinadin A (1) was a novel bromotyrosine alkaloid possessing an N-imidazolyl-quinolinone moiety. Ceratinadins A (1) and B (2) showed antifungal activity.

Original language	English
Pages (from-to)	4569-4572
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2010.06.015
Publication status	Published - Aug 1 2010
Externally published	Yes

Keywords

Bromotyrosine alkaloids
Ceratinadins A-C
Pseudoceratina sp.
Verongid sponge

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2010.06.015

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@article{5fc4334540a9406188f28b55dc0fb974,

title = "Ceratinadins A-C, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp.",

abstract = "Three new bromotyrosine alkaloids, ceratinadins A-C (1-3), were isolated from an Okinawan marine sponge Pseudoceratina sp. and the structures of 1-3 were elucidated on the basis of spectroscopic data. Ceratinadin A (1) was a novel bromotyrosine alkaloid possessing an N-imidazolyl-quinolinone moiety. Ceratinadins A (1) and B (2) showed antifungal activity.",

keywords = "Bromotyrosine alkaloids, Ceratinadins A-C, Pseudoceratina sp., Verongid sponge",

author = "Yuji Kon and Takaaki Kubota and Azusa Shibazaki and Tohru Gonoi and Jun'Ichi Kobayashi",

note = "Funding Information: We thank Mr. Z. Nagahama for his help with sponge collection, Dr. E. Fukushi, Graduate School of Agriculture, Hokkaido University, for measurement of 1 H– 15 N HMBC spectrum, and Ms. S. Oka, Center for Instrumental Analysis, Hokkaido University, for measurements of ESIMS. This work was supported by Grant-in-Aid for Science Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.",

year = "2010",

month = aug,

day = "1",

doi = "10.1016/j.bmcl.2010.06.015",

language = "English",

volume = "20",

pages = "4569--4572",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "15",

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TY - JOUR

T1 - Ceratinadins A-C, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp.

AU - Kon, Yuji

AU - Kubota, Takaaki

AU - Shibazaki, Azusa

AU - Gonoi, Tohru

AU - Kobayashi, Jun'Ichi

N1 - Funding Information: We thank Mr. Z. Nagahama for his help with sponge collection, Dr. E. Fukushi, Graduate School of Agriculture, Hokkaido University, for measurement of 1 H– 15 N HMBC spectrum, and Ms. S. Oka, Center for Instrumental Analysis, Hokkaido University, for measurements of ESIMS. This work was supported by Grant-in-Aid for Science Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Three new bromotyrosine alkaloids, ceratinadins A-C (1-3), were isolated from an Okinawan marine sponge Pseudoceratina sp. and the structures of 1-3 were elucidated on the basis of spectroscopic data. Ceratinadin A (1) was a novel bromotyrosine alkaloid possessing an N-imidazolyl-quinolinone moiety. Ceratinadins A (1) and B (2) showed antifungal activity.

AB - Three new bromotyrosine alkaloids, ceratinadins A-C (1-3), were isolated from an Okinawan marine sponge Pseudoceratina sp. and the structures of 1-3 were elucidated on the basis of spectroscopic data. Ceratinadin A (1) was a novel bromotyrosine alkaloid possessing an N-imidazolyl-quinolinone moiety. Ceratinadins A (1) and B (2) showed antifungal activity.

KW - Bromotyrosine alkaloids

KW - Ceratinadins A-C

KW - Pseudoceratina sp.

KW - Verongid sponge

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U2 - 10.1016/j.bmcl.2010.06.015

DO - 10.1016/j.bmcl.2010.06.015

M3 - Article

C2 - 20584605

AN - SCOPUS:77955415279

VL - 20

SP - 4569

EP - 4572

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 15

ER -

Ceratinadins A-C, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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