Ceratinadins A-C, new bromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp.

Yuji Kon, Takaaki Kubota, Azusa Shibazaki, Tohru Gonoi, Jun'Ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Three new bromotyrosine alkaloids, ceratinadins A-C (1-3), were isolated from an Okinawan marine sponge Pseudoceratina sp. and the structures of 1-3 were elucidated on the basis of spectroscopic data. Ceratinadin A (1) was a novel bromotyrosine alkaloid possessing an N-imidazolyl-quinolinone moiety. Ceratinadins A (1) and B (2) showed antifungal activity.

Original languageEnglish
Pages (from-to)4569-4572
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number15
DOIs
Publication statusPublished - Aug 1 2010
Externally publishedYes

Keywords

  • Bromotyrosine alkaloids
  • Ceratinadins A-C
  • Pseudoceratina sp.
  • Verongid sponge

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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